Cell Cycle Antibodies 1
Anti-TNKS Antibody (CAB17027)
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- SKU:
- CAB17027
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-TNKS Antibody |
| Antibody SKU: | CAB17027 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human TNKS (NP_003738.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human TNKS (NP_003738.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EQIT LDVL ADMG HEEL KEIG INAY GHRH KLIK GVER LLGG QQGT NPYL TFHC VNQG TILL DLAP EDKE YQSV EEEM QSTI REHR DGGN AGGI FNRY NVIR I |
| Gene ID: | 8658 |
| Uniprot: | O95271 |
| Cellular Location: | |
| Calculated MW: | 67kDa/142kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TNKS, ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5, tankyrase |
| Background: |
| UniProt Protein Function: | TNKS: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.4.2.30; Transferase Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: Golgi membrane; spindle pole; Golgi apparatus; pericentriolar material; chromosome, telomeric region; nuclear membrane; nuclear chromosome, telomeric region; nuclear pore; cytosol; chromosome, pericentric region Molecular Function:protein binding; zinc ion binding; NAD+ ADP-ribosyltransferase activity Biological Process: mitosis; protein polyubiquitination; mRNA transport; Wnt receptor signaling pathway; peptidyl-threonine phosphorylation; spindle assembly; negative regulation of DNA binding; positive regulation of telomere maintenance via telomerase; peptidyl-serine phosphorylation; protein amino acid ADP-ribosylation; protein transport; mitotic spindle organization and biogenesis; cell division; positive regulation of transcription from RNA polymerase II promoter; regulation of telomere maintenance via telomerase |
| UniProt Code: | O95271 |
| NCBI GenInfo Identifier: | 226693566 |
| NCBI Gene ID: | 8658 |
| NCBI Accession: | O95271.2 |
| UniProt Related Accession: | O95271 |
| Molecular Weight: | 67kDa; 142kDa |
| NCBI Full Name: | Poly |
| NCBI Synonym Full Names: | tankyrase |
| NCBI Official Symbol: | TNKS |
| NCBI Official Synonym Symbols: | TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a |
| NCBI Protein Information: | poly [ADP-ribose] polymerase tankyrase-1 |
| UniProt Protein Name: | Tankyrase-1 |
| UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; Poly [ADP-ribose] polymerase 5A; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase I |
| Protein Family: | Tankyrase |
| UniProt Gene Name: | TNKS |
| UniProt Entry Name: | TNKS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNKS antibody (CAB17027) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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