Cell Death Antibodies 2
Anti-TNIP2 Antibody (CAB4962)
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- SKU:
- CAB4962
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TNIP2
- Synonyms:
- ABIN2
- Synonyms:
- FLIP1
- Synonyms:
- KLIP
- Research Area:
- Cell Death
Description
| Product Name: | TNIP2 Rabbit pAb |
| Product Code: | CAB4962 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | TNIP2, ABIN2, FLIP1, KLIP |
| Applications: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-429 of human TNIP2 (NP_077285.3). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-429 of human TNIP2 (NP_077285.3). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLHA QLRG LQIP HEPE LMRK EISR LNRQ LEEK INDC AEVK QELA ASRT ARDA ALER VQML EQQI LAYK DDFM SERA DRER AQSR IQEL EEKV ASLL HQVS WRQD SREP DAGR IHAG SKTA KYLA ADAL ELMV PGGW RPGT GSQQ PEPP AEGG HPGA AQRG QGDL QCPH CLQC FSDE QGEE LLRH VAEC CQ |
| Gene ID: | 79155 |
| Uniprot: | Q8NFZ5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 36kDa/48kDa |
| Observed MW: | 49kDa |
| UniProt Protein Function: | TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:polyubiquitin binding; protein binding; protein kinase binding Biological Process: positive regulation of B cell activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; stress-activated MAPK cascade; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway |
| NCBI Summary: | This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014] |
| UniProt Code: | Q8NFZ5 |
| NCBI GenInfo Identifier: | 74715616 |
| NCBI Gene ID: | 79155 |
| NCBI Accession: | Q8NFZ5.1 |
| UniProt Secondary Accession: | Q8NFZ5,Q7L5L2, Q9BQR6, Q9H682, B1AKS4, B3KTY8, D3DVQ9 |
| UniProt Related Accession: | Q8NFZ5 |
| Molecular Weight: | 36,682 Da |
| NCBI Full Name: | TNFAIP3-interacting protein 2 |
| NCBI Synonym Full Names: | TNFAIP3 interacting protein 2 |
| NCBI Official Symbol: | TNIP2 |
| NCBI Official Synonym Symbols: | KLIP; ABIN2; FLIP1 |
| NCBI Protein Information: | TNFAIP3-interacting protein 2 |
| UniProt Protein Name: | TNFAIP3-interacting protein 2 |
| UniProt Synonym Protein Names: | A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein |
| Protein Family: | TNFAIP3-interacting protein |
| UniProt Gene Name: | TNIP2 |
| UniProt Entry Name: | TNIP2_HUMAN |
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