Cell Biology Antibodies 13

Anti-TNIK Antibody (CAB17103)

(No reviews yet) Write a Review
SKU:
CAB17103
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TNIK Antibody
Antibody SKU:CAB17103
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human TNIK.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide of human TNIK.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23043
Uniprot:Q9UKE5
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:TNIK, MRT54
Background:Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).
UniProt Protein Function:TNIK: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, STE; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: apical plasma membrane; cytoplasm; cytoskeleton; nucleoplasm; nucleus

Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; activation of JNKK activity; cytoskeleton organization and biogenesis; microvillus biogenesis; positive regulation of defense response to virus by host; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite morphogenesis

NCBI Summary:Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9UKE5
NCBI GenInfo Identifier:29840818
NCBI Gene ID:23043
NCBI Accession:Q9UKE5.1
UniProt Secondary Accession:Q9UKE5,O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1 Q9UKE2, Q9UKE3, A7E2A3, A8K4U1, D3DNQ6,
UniProt Related Accession:Q9UKE5
Molecular Weight:144,251 Da
NCBI Full Name:TRAF2 and NCK-interacting protein kinase
NCBI Synonym Full Names:TRAF2 and NCK interacting kinase
NCBI Official Symbol:TNIK  
NCBI Official Synonym Symbols:MRT54  
NCBI Protein Information:TRAF2 and NCK-interacting protein kinase
UniProt Protein Name:TRAF2 and NCK-interacting protein kinase
Protein Family:TRAF2 and NCK-interacting protein kinase
UniProt Gene Name:TNIK  
UniProt Entry Name:TNIK_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products