Cell Biology Antibodies 12

Anti-TNFSF8 Antibody (CAB8541)

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SKU:
CAB8541
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TNFSF8 Antibody
Antibody SKU:CAB8541
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 62-234 of human TNFSF8 (NP_001235.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, B cells, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 62-234 of human TNFSF8 (NP_001235.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQRT DSIP NSPD NVPL KGGN CSED LLCI LKRA PFKK SWAY LQVA KHLN KTKL SWNK DGIL HGVR YQDG NLVI QFPG LYFI ICQL QFLV QCPN NSVD LKLE LLIN KHIK KQAL VTVC ESGM QTKH VYQN LSQF LLDY LQVN TTIS VNVD TFQY IDTS TFPL ENVL SIFL YSNS D
Gene ID:944
Uniprot:P32971
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:26kDa
Observed MW:46kDa
Synonyms:TNFSF8, CD153, CD30L, CD30LG, TNLG3A
Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; cell-cell signaling; apoptosis; positive regulation of transcription from RNA polymerase II promoter; immune response; signal transduction

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:P32971
NCBI GenInfo Identifier:416777
NCBI Gene ID:944
NCBI Accession:P32971.1
UniProt Secondary Accession:P32971,O43404,
UniProt Related Accession:P32971
Molecular Weight:26,017 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 8
NCBI Synonym Full Names:tumor necrosis factor (ligand) superfamily, member 8
NCBI Official Symbol:TNFSF8  
NCBI Official Synonym Symbols:CD153; CD30L; CD30LG  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 8
UniProt Synonym Protein Names:CD30 ligand; CD30-L; CD_antigen: CD153
UniProt Gene Name:TNFSF8  
UniProt Entry Name:TNFL8_HUMAN
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