Immunology Antibodies 2
Anti-TNFSF13B Antibody (CAB5858)
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- SKU:
- CAB5858
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TNFSF13B Antibody |
| Antibody SKU: | CAB5858 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 76-285 of human TNFSF13B (NP_006564.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, THP-1, A-549, HepG2, U-87MG, HeLa, A673, Mouse lung, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 76-285 of human TNFSF13B (NP_006564.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LASL RAEL QGHH AEKL PAGA GAPK AGLE EAPA VTAG LKIF EPPA PGEG NSSQ NSRN KRAV QGPE ETVT QDCL QLIA DSET PTIQ KGSY TFVP WLLS FKRG SALE EKEN KILV KETG YFFI YGQV LYTD KTYA MGHL IQRK KVHV FGDE LSLV TLFR CIQN MPET LPNN SCYS AGIA KLEE GDEL QLAI PREN AQIS LDGD VTFF GALK LL |
| Gene ID: | 10673 |
| Uniprot: | Q9Y275 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 17kDa/29kDa/31kDa |
| Observed MW: | 42kDa |
| Synonyms: | TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4 |
| Background: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Cytokine; Cell cycle regulation Chromosomal Location of Human Ortholog: 13q32-q34 Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane Molecular Function:protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q9Y275 |
| NCBI GenInfo Identifier: | 13124573 |
| NCBI Gene ID: | 10673 |
| NCBI Accession: | Q9Y275.1 |
| UniProt Secondary Accession: | Q9Y275,Q6FHD6, Q7Z5J2, E0ADT7, |
| UniProt Related Accession: | Q9Y275 |
| Molecular Weight: | 17,578 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 13B |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 13b |
| NCBI Official Symbol: | TNFSF13B |
| NCBI Official Synonym Symbols: | DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20 |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20 |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 13B |
| UniProt Synonym Protein Names: | B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form |
| UniProt Gene Name: | TNFSF13B |
| UniProt Entry Name: | TN13B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNFSF13B antibody (CAB5858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using TNFSF13B Rabbit pAb (CAB5858) at dilution of 1:100 (40x lens). |
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