Immunology Antibodies 1
Anti-TNFSF13 Antibody (CAB1237)
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- SKU:
- CAB1237
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TNFSF13 Antibody |
| Antibody SKU: | CAB1237 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-247 of human TNFSF13 (NP_742085.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HT-29, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-247 of human TNFSF13 (NP_742085.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVLT QKQK KQHS VLHL VPIN ATSK DDSD VTEV MWQP ALRR GRGL QAQG YGVR IQDA GVYL LYSQ VLFQ DVTF TMGQ VVSR EGQG RQET LFRC IRSM PSHP DRAY NSCY SAGV FHLH QGDI LSVI IPRA RAKL NLSP HGTF LGL |
| Gene ID: | 8741 |
| Uniprot: | O75888 |
| Cellular Location: | Secreted |
| Calculated MW: | 22kDa/24kDa/25kDa/27kDa/36kDa |
| Observed MW: | 35kDa |
| Synonyms: | TNFSF13, APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2 |
| Background: | The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |
| UniProt Protein Function: | TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: cytoplasm; cytosol; external side of plasma membrane; extracellular region; extracellular space; nucleoplasm Molecular Function:cytokine activity; receptor binding; tumor necrosis factor receptor binding Biological Process: gene expression; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of isotype switching to IgA isotypes; regulation of mRNA stability; signal transduction; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] |
| UniProt Code: | O75888 |
| NCBI GenInfo Identifier: | 13124605 |
| NCBI Gene ID: | 8741 |
| NCBI Accession: | O75888.1 |
| UniProt Secondary Accession: | O75888,Q541E1, Q5U0G8, Q96HV6, Q9P1M8, Q9P1M9, A8MYD5 B4DVT2, |
| UniProt Related Accession: | O75888 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 13 |
| NCBI Synonym Full Names: | tumor necrosis factor superfamily member 13 |
| NCBI Official Symbol: | TNFSF13 |
| NCBI Official Synonym Symbols: | APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715 |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 13 |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 13 |
| UniProt Synonym Protein Names: | A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256 |
| UniProt Gene Name: | TNFSF13 |
| UniProt Entry Name: | TNF13_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNFSF13 antibody (CAB1237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TNFSF13 antibody (CAB1237) at dilution of 1:100 (40x lens). |
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