Cell Death Antibodies 1

Anti-TNFSF10 Antibody (CAB2138)

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SKU:
CAB2138
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-TNFSF10 Antibody
Antibody SKU:CAB2138
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-250 of human TNFSF10 (NP_003801.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-250 of human TNFSF10 (NP_003801.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TNEL KQMQ DKYS KSGI ACFL KEDD SYWD PNDE ESMN SPCW QVKW QLRQ LVRK MILR TSEE TIST VQEK QQNI SPLV RERG PQRV AAHI TGTR GRSN TLSS PNSK NEKA LGRK INSW ESSR SGHS FLSN LHLR NGEL VIHE KGFY YIYS QTYF RFQE EIKE NTKN DKQM VQYI YKYT SYPD PILL MKSA RNSC WSKD AEYG LYSI YQGG IFEL
Gene ID:8743
Uniprot:P50591
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:11kDa/32kDa
Observed MW:28kDa
Synonyms:TNFSF10, APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL
Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:P50591
NCBI GenInfo Identifier:1730015
NCBI Gene ID:8743
NCBI Accession:P50591.1
UniProt Secondary Accession:P50591,A1Y9B3,
UniProt Related Accession:P50591
Molecular Weight:11,746 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 10
NCBI Synonym Full Names:TNF superfamily member 10
NCBI Official Symbol:TNFSF10  
NCBI Official Synonym Symbols:TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 10
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 10
UniProt Synonym Protein Names:Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253
UniProt Gene Name:TNFSF10  
Anti-TNFSF10 Antibody (CAB2138)Western blot analysis of extracts of mouse kidney, using TNFSF10 antibody (CAB2138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
Anti-TNFSF10 Antibody (CAB2138)Western blot analysis of extracts of various cell lines, using TNFSF10 antibody (CAB2138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TNFSF10 Antibody (CAB2138)Immunohistochemistry of paraffin-embedded human colon carcinoma using TNFSF10 antibody (CAB2138) at dilution of 1:200 (40x lens).
Anti-TNFSF10 Antibody (CAB2138)Immunohistochemistry of paraffin-embedded human prostate using TNFSF10 antibody (CAB2138) at dilution of 1:200 (40x lens).
Anti-TNFSF10 Antibody (CAB2138)Immunohistochemistry of paraffin-embedded mouse kidney using TNFSF10 antibody (CAB2138) at dilution of 1:200 (40x lens).
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