Name: Anti-TNFRSF8 Antibody (CAB7651)
Brand: Cell Biology Antibodies 11
SKU: CAB7651
Availability: OutOfStock

Antibody Name:	Anti-TNFRSF8 Antibody
Antibody SKU:	CAB7651
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human TNFRSF8

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HeLa, Jurkat, H460

Immunogen:	A synthetic peptide of human TNFRSF8
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	943
Uniprot:	P28908
Cellular Location:	Cell membrane, Cytoplasm, Single-pass type I membrane protein
Calculated MW:	14kDa/50kDa/63kDa
Observed MW:	128kDa

Synonyms:

TNFRSF8, CD30, D1S166E, Ki-1

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

UniProt Protein Function:	TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction
NCBI Summary:	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:	P28908
NCBI GenInfo Identifier:	115978
NCBI Gene ID:	943
NCBI Accession:	P28908.1
UniProt Secondary Accession:	P28908,Q6P4D9, B1AN79, B9EGD9, D3YTD8,
UniProt Related Accession:	P28908
Molecular Weight:	50,935 Da
NCBI Full Name:	Tumor necrosis factor receptor superfamily member 8
NCBI Synonym Full Names:	tumor necrosis factor receptor superfamily, member 8
NCBI Official Symbol:	TNFRSF8
NCBI Official Synonym Symbols:	CD30; Ki-1; D1S166E
NCBI Protein Information:	tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
UniProt Protein Name:	Tumor necrosis factor receptor superfamily member 8
UniProt Synonym Protein Names:	CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
UniProt Gene Name:	TNFRSF8
UniProt Entry Name:	TNR8_HUMAN

Western blot analysis of extracts of various cell lines, using TNFRSF8 antibody (CAB7651) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

ELISA Kits

Human CD30 / TNFRSF8 ELISA Kit

Human CD30 (Cluster of Differentiation 30) ELISA Kit (HUES01893)

Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)