Cell Death Antibodies 1
Anti-TNFRSF19 Antibody (CAB14284)
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- SKU:
- CAB14284
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-TNFRSF19 Antibody |
| Antibody SKU: | CAB14284 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human TNFRSF19 (NP_061117.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | DU145, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human TNFRSF19 (NP_061117.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESGD CRQQ EFRD RSGN CVPC NQCG PGME LSKE CGFG YGED AQCV TCRL HRFK EDWG FQKC KPCL DCAV VNRF QKAN CSAT SDAI CGDC LPGF YRKT KLVG FQDM ECVP CGDP PPPY EPHC ASKV NLVK IAST ASSP RDTA L |
| Gene ID: | 55504 |
| Uniprot: | Q9NS68 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 30kDa/45kDa/46kDa |
| Observed MW: | 46kDa |
| Synonyms: | TNFRSF19, TAJ, TAJ-alpha, TRADE, TROY |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | TNFRSF19: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q12.12 Cellular Component: plasma membrane Molecular Function:receptor activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; tissue development |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NS68 |
| NCBI GenInfo Identifier: | 325120959 |
| NCBI Gene ID: | 55504 |
| NCBI Accession: | NP_001191387.1 |
| UniProt Secondary Accession: | Q9NS68,Q9BXZ9, Q9BY00, Q9NZV2, A8KA09, A8KA26, B1AM40 B1AM41, B4E2I6, |
| UniProt Related Accession: | Q9NS68 |
| Molecular Weight: | 30,542 Da |
| NCBI Full Name: | tumor necrosis factor receptor superfamily member 19 isoform 2 |
| NCBI Synonym Full Names: | TNF receptor superfamily member 19 |
| NCBI Official Symbol: | TNFRSF19 |
| NCBI Official Synonym Symbols: | TAJ; TROY; TRADE; TAJ-alpha |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 19 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 19 |
| UniProt Synonym Protein Names: | TRADE; Toxicity and JNK inducer |
| UniProt Gene Name: | TNFRSF19 |
 | Western blot analysis of extracts of various cell lines, using TNFRSF19 antibody (CAB14284) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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