Anti-TNFRSF17 Antibody (CAB10707)

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SKU:
CAB10707
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TNFRSF17
Synonyms:
BCM
Synonyms:
BCMA
Synonyms:
CD269
Synonyms:
TNFRSF13A

Description

Product Name:TNFRSF17 Rabbit pAb
Product Code:CAB10707
Size:20uL, 50uL, 100uL
Synonyms:TNFRSF17, BCM, BCMA, CD269, TNFRSF13A
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFRSF17 (NP_001183.2).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SP2/0, Raji, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFRSF17 (NP_001183.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLQM AGQC SQNE YFDS LLHA CIPC QLRC SSNT PPLT CQRY CNAS VTNS VKGT NAIL WTCL GLSL IISL AVFV LMFL LRKI NSEP LKDE FKNT GSGL LGMA
Gene ID:608
Uniprot:Q02223
Cellular Location:Cell membrane, Endomembrane system, Single-pass type III membrane protein
Calculated MW:14kDa/20kDa
Observed MW:15-35kDa
UniProt Protein Function:TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 16p13.1Cellular Component: endomembrane system; integral to membrane; plasma membraneMolecular Function: receptor activityBiological Process: adaptive immune response; cell proliferation; lymphocyte homeostasis; multicellular organismal development; signal transduction; tumor necrosis factor-mediated signaling pathway
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
UniProt Code:Q02223
NCBI GenInfo Identifier:313104029
NCBI Gene ID:608
NCBI Accession:Q02223.2
UniProt Secondary Accession:Q02223,Q2TQ40
UniProt Related Accession:Q02223
Molecular Weight:14,843 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 17
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily member 17
NCBI Official Symbol:TNFRSF17  
NCBI Official Synonym Symbols:BCM; BCMA; CD269; TNFRSF13A  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 17
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names:B-cell maturation protein; CD_antigen: CD269
Protein Family:
UniProt Gene Name:TNFRSF17  
UniProt Entry Name:TNR17_HUMAN
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