Cardiovascular Antibodies

Anti-TNFRSF12A Antibody (CAB13093)

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SKU:
CAB13093
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TNFRSF12A Antibody
Antibody SKU:CAB13093
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-129 of human TNFRSF12A (NP_057723.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-1080
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-129 of human TNFRSF12A (NP_057723.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EQAP GTAP CSRG SSWS ADLD KCMD CASC RARP HSDF CLGC AAAP PAPF RLLW PILG GALS LTFV LGLL SGFL VWRR CRRR EKFT TPIE ETGG EGCP AVAL IQ
Gene ID:51330
Uniprot:Q9NP84
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:10kDa/13kDa
Observed MW:14kDa
Synonyms:TNFRSF12A, CD266, FN14, TWEAKR
Background:
UniProt Protein Function:TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function:protein binding

Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis

UniProt Code:Q9NP84
NCBI GenInfo Identifier:21263626
NCBI Gene ID:51330
NCBI Accession:Q9NP84.1
UniProt Secondary Accession:Q9NP84,Q9HCS0, D3DUA6,
UniProt Related Accession:Q9NP84
Molecular Weight:10,191 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 12A
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol:TNFRSF12A  
NCBI Official Synonym Symbols:FN14; CD266; TWEAKR  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names:Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
UniProt Gene Name:TNFRSF12A  
UniProt Entry Name:TNR12_HUMAN
Anti-TNFRSF12A Antibody (CAB13093)Western blot analysis of extracts of HT-1080 cells, using TNFRSF12A antibody (CAB13093) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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