Cell Death Antibodies 2
Anti-TNFRSF10D Antibody (CAB6136)
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- SKU:
- CAB6136
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-TNFRSF10D Antibody |
| Antibody SKU: | CAB6136 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-386 of human TNFRSF10D (NP_003831.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-386 of human TNFRSF10D (NP_003831.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLFR RRSC PSRV PGAE DNAR NETL SNRY LQPT QVSE QEIQ GQEL AELT GVTV ELPE EPQR LLEQ AEAE GCQR RRLL VPVN DADS ADIS TLLD ASAT LEEG HAKE TIQD QLVG SEKL FYEE DEAG SATS CL |
| Gene ID: | 8793 |
| Uniprot: | Q9UBN6 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. |
| UniProt Protein Function: | TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8p21 Cellular Component: integral to membrane Molecular Function:transmembrane receptor activity; TRAIL binding Biological Process: apoptosis; signal transduction; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBN6 |
| NCBI GenInfo Identifier: | 18203495 |
| NCBI Gene ID: | 8793 |
| NCBI Accession: | Q9UBN6.1 |
| UniProt Secondary Accession: | Q9UBN6,Q9Y6Q4, B2R8W0, |
| UniProt Related Accession: | Q9UBN6 |
| Molecular Weight: | 41,823 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10D |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| NCBI Official Symbol: | TNFRSF10D |
| NCBI Official Synonym Symbols: | DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4 |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10D; TRAIL receptor 4; decoy receptor 2; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10D |
| UniProt Synonym Protein Names: | Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD_antigen: CD264 |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | TNFRSF10D |
| UniProt Entry Name: | TR10D_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNFRSF10D antibody (CAB6136) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
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