Cell Death Antibodies 1

Anti-TNFRSF10C Antibody (CAB1137)

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SKU:
CAB1137
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-TNFRSF10C Antibody
Antibody SKU:CAB1137
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human TNFRSF10C (NP_003832.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human TNFRSF10C (NP_003832.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RQEE VPQQ TVAP QQQR HSFK GEEC PAGS HRSE HTGA CNPC TEGV DYTN ASNN EPSC FPCT VCKS DQKH KSSC TMTR DTVC QCKE GTFR NENS PEMC RKCS R
Gene ID:8794
Uniprot:O14798
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:27kDa
Observed MW:27kDa
Synonyms:TNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID
Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
UniProt Protein Function:TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function:transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
UniProt Code:O14798
NCBI GenInfo Identifier:269849734
NCBI Gene ID:8794
NCBI Accession:O14798.3
UniProt Secondary Accession:O14798,O14755, Q08AS6, Q6FH98, Q6UXM5,
UniProt Related Accession:O14798
Molecular Weight:259
NCBI Full Name:Tumor necrosis factor receptor superfamily member 10C
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
NCBI Official Symbol:TNFRSF10C  
NCBI Official Synonym Symbols:LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligan
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names:Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
Protein Family:Protein
UniProt Gene Name:TNFRSF10C  
UniProt Entry Name:TR10C_HUMAN
Anti-TNFRSF10C Antibody (CAB1137)Western blot analysis of extracts of various cell lines, using TNFRSF10C antibody (CAB1137) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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