Immunology Antibodies 1
Anti-TNFAIP8L2 Antibody (CAB13698)
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- SKU:
- CAB13698
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TNFAIP8L2 Antibody |
| Antibody SKU: | CAB13698 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human TNFAIP8L2 (NP_078851.2). |
| Application: | WB IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Mouse thymus, Mouse spleen, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human TNFAIP8L2 (NP_078851.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESF SSKS LALQ AEKK LLSK MAGR SVAH LFID ETSS EVLD ELYR VSKE YTHS RPQA QRVI KDLI KVAI KVAV LHRN GSFG PSEL ALAT RFRQ KLRQ GAMT ALSF GEVD FTFE AAVL AGLL TECR DVLL ELVE HHLT PKSH GRIR HVFD HFSD PGLL TALY GPDF TQHL GKIC DGLR KLLD EGKL |
| Gene ID: | 79626 |
| Uniprot: | Q6P589 |
| Cellular Location: | |
| Calculated MW: | 20kDa |
| Observed MW: | 18KDa |
| Synonyms: | TNFAIP8L2, TIPE2 |
| Background: |
| UniProt Protein Function: | TNFAIP8L2: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: negative regulation of inflammatory response; negative regulation of T cell activation |
| UniProt Code: | Q6P589 |
| NCBI GenInfo Identifier: | 74749120 |
| NCBI Gene ID: | 79626 |
| NCBI Accession: | Q6P589.1 |
| UniProt Secondary Accession: | Q6P589,Q6I9Y0, Q9H2H7, Q9H5G2, |
| UniProt Related Accession: | Q6P589 |
| Molecular Weight: | 20,556 Da |
| NCBI Full Name: | Tumor necrosis factor alpha-induced protein 8-like protein 2 |
| NCBI Synonym Full Names: | TNF alpha induced protein 8 like 2 |
| NCBI Official Symbol: | TNFAIP8L2 |
| NCBI Official Synonym Symbols: | TIPE2 |
| NCBI Protein Information: | tumor necrosis factor alpha-induced protein 8-like protein 2 |
| UniProt Protein Name: | Tumor necrosis factor alpha-induced protein 8-like protein 2 |
| UniProt Synonym Protein Names: | Inflammation factor protein 20 |
| Protein Family: | Tumor necrosis factor alpha-induced protein 8-like protein |
| UniProt Gene Name: | TNFAIP8L2 |
| UniProt Entry Name: | TP8L2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNFAIP8L2 Polyclonal Antibody (CAB13698) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of C6 cells using TNFAIP8L2 antibody (CAB13698) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using TNFAIP8L2 antibody (CAB13698) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using TNFAIP8L2 antibody (CAB13698) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunoprecipitation analysis of 25ug extracts of Mouse spleen cells using 3ug TNFAIP8L2 antibody (CAB13698). Western blot was performed from the immunoprecipitate using TNFAIP8L2 antibody (CAB13698) at a dilition of 1:1000. |
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