Cell Biology Antibodies 10

Anti-TNFAIP6 Antibody (CAB6419)

(No reviews yet) Write a Review
SKU:
CAB6419
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TNFAIP6 Antibody
Antibody SKU:CAB6419
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-277 of human TNFAIP6 (NP_009046.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-277 of human TNFAIP6 (NP_009046.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WGFK DGIF HNSI WLER AAGV YHRE ARSG KYKL TYAE AKAV CEFE GGHL ATYK QLEA ARKI GFHV CAAG WMAK GRVG YPIV KPGP NCGF GKTG IIDY GIRL NRSE RWDA YCYN PHAK ECGG VFTD PKQI FKSP GFPN EYED NQIC YWHI RLKY GQRI HLSF LDFD LEDD PGCL ADYV EIYD SYDD VHGF VGRY CGDE LPDD IIST GNVM TLKF LSDA SVTA GGFQ IKYV AMDP VSKS SQGK NTST TSTG NKNF LAGR FSHL
Gene ID:7130
Uniprot:P98066
Cellular Location:
Calculated MW:31kDa
Observed MW:40kDa
Synonyms:TNFAIP6, TSG-6, TSG6
Background:The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
UniProt Protein Function:TNFAIP6: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q23.3

Cellular Component: extracellular space

Molecular Function:hyaluronic acid binding

Biological Process: ovulation; cell-cell signaling; signal transduction; inflammatory response; cell adhesion; positive regulation of cell migration

NCBI Summary:The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
UniProt Code:P98066
NCBI GenInfo Identifier:68067717
NCBI Gene ID:7130
NCBI Accession:P98066.2
UniProt Secondary Accession:P98066,Q53TI7, Q8WWI9,
UniProt Related Accession:P98066
Molecular Weight:277
NCBI Full Name:Tumor necrosis factor-inducible gene 6 protein
NCBI Synonym Full Names:tumor necrosis factor, alpha-induced protein 6
NCBI Official Symbol:TNFAIP6  
NCBI Official Synonym Symbols:TSG6; TSG-6  
NCBI Protein Information:tumor necrosis factor-inducible gene 6 protein; TNF alpha-induced protein 6; hyaluronate-binding protein; TNF-stimulated gene 6 protein; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein
UniProt Protein Name:Tumor necrosis factor-inducible gene 6 protein
UniProt Synonym Protein Names:Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6
Protein Family:Tumor necrosis factor-inducible gene 6 protein
UniProt Gene Name:TNFAIP6  
UniProt Entry Name:TSG6_HUMAN
Anti-TNFAIP6 Antibody (CAB6419)Western blot analysis of extracts of mouse brain, using TNFAIP6 Antibody (CAB6419) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
Anti-TNFAIP6 Antibody (CAB6419)Immunohistochemistry of paraffin-embedded human stomach using TNFAIP6 antibody (CAB6419) at dilution of 1:100 (40x lens).
Anti-TNFAIP6 Antibody (CAB6419)Immunohistochemistry of paraffin-embedded rat kidney using TNFAIP6 antibody (CAB6419) at dilution of 1:100 (40x lens).
Anti-TNFAIP6 Antibody (CAB6419)Immunohistochemistry of paraffin-embedded mouse heart using TNFAIP6 antibody (CAB6419) at dilution of 1:100 (40x lens).
View AllClose

0 Reviews

View AllClose

Related Products