Cell Biology Antibodies 13
Anti-TNFAIP1 Antibody (CAB17543)
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- SKU:
- CAB17543
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TNFAIP1 Antibody |
| Antibody SKU: | CAB17543 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human TNFAIP1 (NP_066960.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human TNFAIP1 (NP_066960.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DTIT LPQN RQEI KELM AEAK YYLI QGLV NMCQ SALQ DKKD SYQP VCNI PIIT SLKE EERL IESS TKPV VKL |
| Gene ID: | 7126 |
| Uniprot: | Q13829 |
| Cellular Location: | |
| Calculated MW: | 24kDa/36kDa |
| Observed MW: | 36kDa |
 | Western blot - TNFAIP1 Rabbit pAb (CAB17543) |
| Synonyms: | B12, B61, BTBD34, EDP1, hBACURD2, TNFAIP1 |
| Background: | This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family. |
| UniProt Protein Details: | Protein type:DNA replication; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q22-q23 Cellular Component: cytoplasm; nucleolus; endosome Molecular Function:protein domain specific binding; protein binding; GTP-Rho binding; ubiquitin-protein ligase activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; embryonic development; cell migration; negative regulation of Rho protein signal transduction; apoptosis; stress fiber formation; protein ubiquitination; immune response; DNA replication; protein homooligomerization; positive regulation of DNA replication |
| NCBI Summary: | This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13829 |
| NCBI GenInfo Identifier: | 2833248 |
| NCBI Gene ID: | 7126 |
| NCBI Accession: | Q13829.1 |
| UniProt Secondary Accession: | Q13829,Q5TZQ1, |
| UniProt Related Accession: | Q13829 |
| Molecular Weight: | 36,204 Da |
| NCBI Full Name: | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 |
| NCBI Synonym Full Names: | tumor necrosis factor, alpha-induced protein 1 (endothelial) |
| NCBI Official Symbol: | TNFAIP1 |
| NCBI Official Synonym Symbols: | B12; B61; EDP1; BTBD34; hBACURD2 |
| NCBI Protein Information: | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1 |
| UniProt Protein Name: | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 |
| UniProt Synonym Protein Names: | BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial |
| Protein Family: | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein |
| UniProt Gene Name: | TNFAIP1 |
| UniProt Entry Name: | BACD2_HUMAN |
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