Cell Biology Antibodies 14
Anti-TNC Antibody (CAB18156)
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- SKU:
- CAB18156
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TNC Antibody |
| Antibody SKU: | CAB18156 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TNC. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TNC. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3371 |
| Uniprot: | P24821 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - TNC Rabbit pAb (CAB18156) |
| Synonyms: | 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, TNC |
| Background: |
| UniProt Protein Function: | TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9q33 Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane Molecular Function:syndecan binding Biological Process: axon regeneration in the peripheral nervous system; cell adhesion; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; neuromuscular junction development; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of cell proliferation; response to ethanol; response to mechanical stimulus; response to wounding; wound healing Disease: Deafness, Autosomal Dominant 56 |
| NCBI Summary: | This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] |
| UniProt Code: | P24821 |
| NCBI GenInfo Identifier: | 281185495 |
| NCBI Gene ID: | 3371 |
| NCBI Accession: | P24821.3 |
| UniProt Secondary Accession: | P24821,Q14583, Q15567, Q5T7S3, C9IYT7, C9J575, C9J6D9 C9J848, |
| UniProt Related Accession: | P24821 |
| Molecular Weight: | 171,360 Da |
| NCBI Full Name: | Tenascin |
| NCBI Synonym Full Names: | tenascin C |
| NCBI Official Symbol: | TNC |
| NCBI Official Synonym Symbols: | GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225 |
| NCBI Protein Information: | tenascin |
| UniProt Protein Name: | Tenascin |
| UniProt Synonym Protein Names: | Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C |
| Protein Family: | Tenascin |
| UniProt Gene Name: | TNC |
| UniProt Entry Name: | TENA_HUMAN |
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