Cell Biology Antibodies 1
Anti-TMPRSS15 Antibody (CAB10239)
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- SKU:
- CAB10239
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMPRSS15 Antibody |
| Antibody SKU: | CAB10239 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TMPRSS15 (NP_002763.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, HT-1080, BT-474, Jurkat, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TMPRSS15 (NP_002763.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CLTI KESQ RGAA LGQS HEAR ATFK ITSG VTYN PNLQ DKLS VDFK VLAF DLQQ MIDE IFLS SNLK NEYK NSRV LQFE NGSI IVVF DLFF AQWV SDEN VKEE LIQG LEAN KSSQ LVTF HIDL NSVD ILDK LTTT SHLA TPGN VSIE CLPG SSPC TDAL TCIK ADLF CDGE VNCP DGSD EDNK MCAT VCDG RFLL TGSS GSFQ ATHY PKPS ETSV VCQW IIRV NQGL SIKL SFDD FNTY YTDI LDIY EGVG SSKI LRAS IWET N |
| Gene ID: | 5651 |
| Uniprot: | P98073 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 112kDa |
| Observed MW: | 113kDa |
| Synonyms: | TMPRSS15, ENTK, PRSS7 |
| Background: | This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. |
| UniProt Protein Function: | PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.9; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 21q21.1 Cellular Component: brush border Molecular Function:protein binding Disease: Enterokinase Deficiency |
| NCBI Summary: | This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P98073 |
| NCBI GenInfo Identifier: | 317373442 |
| NCBI Gene ID: | 5651 |
| NCBI Accession: | P98073.3 |
| UniProt Secondary Accession: | P98073,Q2NKL7, |
| UniProt Related Accession: | P98073 |
| Molecular Weight: | Calculated MW: 112kDaObserved MW: 113kDa |
| NCBI Full Name: | Enteropeptidase |
| NCBI Synonym Full Names: | transmembrane protease, serine 15 |
| NCBI Official Symbol: | TMPRSS15 |
| NCBI Official Synonym Symbols: | ENTK; PRSS7 |
| NCBI Protein Information: | enteropeptidase |
| UniProt Protein Name: | Enteropeptidase |
| UniProt Synonym Protein Names: | Enterokinase; Serine protease 7; Transmembrane protease serine 15 |
| Protein Family: | Enteropeptidase |
| UniProt Gene Name: | TMPRSS15 |
 | Western blot analysis of extracts of various cell lines, using TMPRSS15 antibody (CAB10239) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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