Cell Biology Antibodies 5

Anti-TMOD2 Antibody (CAB14881)

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SKU:
CAB14881
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMOD2 Antibody
Antibody SKU:CAB14881
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human TMOD2 (NP_055363.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse testis, Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human TMOD2 (NP_055363.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EEAL ASAS DTEL YDLA AVLG VHNL LNNP KFDE ETAN NKGG KGPV RNVV KGEK VKPV FEEP PNPT NVEI SLQQ MKAN DPSL Q
Gene ID:29767
Uniprot:Q9NZR1
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:35kDa/39kDa
Observed MW:40kDa
Synonyms:TMOD2, N-TMOD, NTMOD
Background:This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:TMOD2: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. Belongs to the tropomodulin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: striated muscle thin filament

Biological Process: actin filament organization; muscle contraction; myofibril assembly; nervous system development

NCBI Summary:This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
UniProt Code:Q9NZR1
NCBI GenInfo Identifier:23396886
NCBI Gene ID:29767
NCBI Accession:Q9NZR1.1
UniProt Secondary Accession:Q9NZR1,B4DEW6,
UniProt Related Accession:Q9NZR1
Molecular Weight:35,648 Da
NCBI Full Name:Tropomodulin-2
NCBI Synonym Full Names:tropomodulin 2
NCBI Official Symbol:TMOD2  
NCBI Official Synonym Symbols:NTMOD; N-TMOD  
NCBI Protein Information:tropomodulin-2
UniProt Protein Name:Tropomodulin-2
UniProt Synonym Protein Names:Neuronal tropomodulin; N-Tmod
Protein Family:Tropomodulin
UniProt Gene Name:TMOD2  
UniProt Entry Name:TMOD2_HUMAN
Anti-TMOD2 Antibody (CAB14881)Western blot analysis of extracts of various cell lines, using TMOD2 antibody (CAB14881) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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