Cell Biology Antibodies 9
Anti-TMOD1 Antibody (CAB4160)
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- SKU:
- CAB4160
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMOD1 Antibody |
| Antibody SKU: | CAB4160 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-359 of human TMOD1 (NP_003266.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, Mouse heart, Mouse skeletal muscle, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-359 of human TMOD1 (NP_003266.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSYR RELE KYRD LDED EILG ALTE EELR TLEN ELDE LDPD NALL PAGL RQKD QTTK APTG PFKR EELL DHLE KQAK EFKD REDL VPYT GEKR GKVW VPKQ KPLD PVLE SVTL EPEL EEAL ANAS DAEL CDIA AILG MHTL MSNQ QYYQ ALSS SSIM NKEG LNSV IKPT QYKP VPDE EPNS TDVE ETLE RIKN NDPK LEEV NLNN IRNI PIPT LKAY AEAL KENS YVKK FSIV GTRS NDPV AYAL AEML KENK VLKT LNVE SNFI SGAG ILRL VEAL PYNT SLVE MKID NQSQ PLGN KVEM EIVS MLEK NATL LKFG YHFT QQGP RLRA SNAM MNNN DLVR KRRL ADLT GPII PKCR SGV |
| Gene ID: | 7111 |
| Uniprot: | P28289 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 26kDa/40kDa |
| Observed MW: | 40kDa |
| Synonyms: | TMOD1, D9S57E, ETMOD, TMOD |
| Background: | This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | TMOD1: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. Belongs to the tropomodulin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Cell development/differentiation; Contractile; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: cytosol; signalosome; striated muscle thin filament Molecular Function:tropomyosin binding Biological Process: actin filament organization; muscle contraction; muscle filament sliding; myofibril assembly |
| NCBI Summary: | This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P28289 |
| NCBI GenInfo Identifier: | 135922 |
| NCBI Gene ID: | 7111 |
| NCBI Accession: | P28289.1 |
| UniProt Secondary Accession: | P28289,Q5T7W3, Q9BUF1, B2RB77, |
| UniProt Related Accession: | P28289 |
| Molecular Weight: | 26,014 Da |
| NCBI Full Name: | Tropomodulin-1 |
| NCBI Synonym Full Names: | tropomodulin 1 |
| NCBI Official Symbol: | TMOD1 |
| NCBI Official Synonym Symbols: | TMOD; ETMOD; D9S57E |
| NCBI Protein Information: | tropomodulin-1 |
| UniProt Protein Name: | Tropomodulin-1 |
| UniProt Synonym Protein Names: | Erythrocyte tropomodulin; E-Tmod |
| Protein Family: | Tropomodulin |
| UniProt Gene Name: | TMOD1 |
| UniProt Entry Name: | TMOD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TMOD1 antibody (CAB4160) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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