Cell Biology Antibodies 4

Anti-TMEM70 Antibody (CAB13712)

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SKU:
CAB13712
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMEM70 Antibody
Antibody SKU:CAB13712
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 161-260 of human TMEM70 (NP_060336.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 161-260 of human TMEM70 (NP_060336.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FITK GYVI RLYH EATT DTYK AITY NAML AETS TVFH QNDV KIPD AKHV FTTF YAKT KSLL VNPV LFPN REDY IHLM GYDK EEFI LYME ETSE EKRH KDDK
Gene ID:54968
Uniprot:Q9BUB7
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:11kDa/18kDa/28kDa
Observed MW:18kDa
Synonyms:TMEM70, MC5DN2
Background:This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.
UniProt Protein Function:TMEM70: Involved in biogenesis of mitochondrial ATP synthase. Defects in TMEM70 are a cause of mitochondrial complex V deficiency nuclear type 2 (MC5DN2). A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. Belongs to the TMEM70 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: mitochondrion; nucleoplasm

Biological Process: mitochondrial proton-transporting ATP synthase complex assembly

Disease: Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 2

NCBI Summary:This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
UniProt Code:Q9BUB7
NCBI GenInfo Identifier:74733203
NCBI Gene ID:54968
NCBI Accession:Q9BUB7.2
UniProt Secondary Accession:Q9BUB7,Q9NWY5, E9PDY9,
UniProt Related Accession:Q9BUB7
Molecular Weight:11,278 Da
NCBI Full Name:Transmembrane protein 70, mitochondrial
NCBI Synonym Full Names:transmembrane protein 70
NCBI Official Symbol:TMEM70  
NCBI Official Synonym Symbols:MC5DN2  
NCBI Protein Information:transmembrane protein 70, mitochondrial
UniProt Protein Name:Transmembrane protein 70, mitochondrial
Protein Family:Transmembrane protein
UniProt Gene Name:TMEM70  
UniProt Entry Name:TMM70_HUMAN
Anti-TMEM70 Antibody (CAB13712)Western blot analysis of extracts of HeLa cells, using TMEM70 antibody (CAB13712) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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