Cell Biology Antibodies 6

Anti-TMEM67 Antibody (CAB15549)

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SKU:
CAB15549
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMEM67 Antibody
Antibody SKU:CAB15549
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 780-940 of human TMEM67 (NP_714915.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 780-940 of human TMEM67 (NP_714915.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSHK CFGY YIHG RSVH GHAD TNME EMNM NLKR EAEN LCSQ RGLV PNTD GQTF EIAI SNQM RQHY DRIH ETLI RKNG PARL LSSS ASTF EQSI KAYH MMNK FLGS FIDH VHKE MDYF IKDK LLLE RILG MEFM EPME KSIF YNDE GYSF SSVL YYGN EATL L
Gene ID:91147
Uniprot:Q5HYA8
Cellular Location:Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Multi-pass membrane protein, cilium basal body, cytoskeleton
Calculated MW:103kDa/111kDa
Observed MW:115kDa
Synonyms:TMEM67, JBTS6, MECKELIN, MKS3, NPHP11, TNEM67, meckelin
Background:The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
UniProt Protein Function:Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).
NCBI Summary:The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]
UniProt Code:Q5HYA8
NCBI GenInfo Identifier:214830753
NCBI Gene ID:91147
NCBI Accession:NP_001135773.1
UniProt Secondary Accession:Q5HYA8,Q3ZCX3, Q7Z5T8, Q8IZ06, B3KRU5, B3KT47, G5E9H2
UniProt Related Accession:Q5HYA8
Molecular Weight:Observed: 112 kDPredicted: 112 kDa
NCBI Full Name:meckelin isoform 2
NCBI Synonym Full Names:transmembrane protein 67
NCBI Official Symbol:TMEM67  
NCBI Official Synonym Symbols:MKS3; JBTS6; NPHP11; TNEM67; MECKELIN  
NCBI Protein Information:meckelin
UniProt Protein Name:Meckelin
UniProt Synonym Protein Names:Meckel syndrome type 3 protein; Transmembrane protein 67
UniProt Gene Name:TMEM67  
Anti-TMEM67 Antibody (CAB15549)Western blot analysis of extracts of various cell lines, using TMEM67 antibody (CAB15549) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
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