Cardiovascular Antibodies

Anti-TMEM55A Antibody (CAB15471)

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SKU:
CAB15471
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-TMEM55A Antibody
Antibody SKU:CAB15471
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-195 of human TMEM55A (NP_061180.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-195 of human TMEM55A (NP_061180.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VMLI SEEQ PAQP ALPI QPEG TRVV CGHC GNTF LWME LRFN TLAK CPHC KKIS SVGS ALPR RRCC AY
Gene ID:55529
Uniprot:Q8N4L2
Cellular Location:Late endosome membrane, Lysosome membrane, Multi-pass membrane protein
Calculated MW:28kDa
Observed MW:28kDa
Synonyms:TMEM55A
Background:
UniProt Protein Function:TMEM55A: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 3.1.3.78; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: integral to membrane; late endosome membrane; lysosomal membrane

Biological Process: phosphoinositide dephosphorylation

NCBI Summary:TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8N4L2
NCBI GenInfo Identifier:24308165
NCBI Gene ID:55529
NCBI Accession:NP_061180.1
UniProt Secondary Accession:Q8N4L2,Q68CU2, B2R9H4,
UniProt Related Accession:Q8N4L2
Molecular Weight:28,081 Da
NCBI Full Name:type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
NCBI Synonym Full Names:transmembrane protein 55A
NCBI Official Symbol:TMEM55A  
NCBI Protein Information:type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
UniProt Protein Name:Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
UniProt Synonym Protein Names:PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A
Protein Family:Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
UniProt Gene Name:TMEM55A  
UniProt Entry Name:TM55A_HUMAN
Anti-TMEM55A Antibody (CAB15471)Western blot analysis of extracts of mouse liver, using TMEM55A antibody (CAB15471) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s.
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