Cardiovascular Antibodies
Anti-TMEM55A Antibody (CAB15471)
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- SKU:
- CAB15471
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-TMEM55A Antibody |
| Antibody SKU: | CAB15471 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-195 of human TMEM55A (NP_061180.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-195 of human TMEM55A (NP_061180.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VMLI SEEQ PAQP ALPI QPEG TRVV CGHC GNTF LWME LRFN TLAK CPHC KKIS SVGS ALPR RRCC AY |
| Gene ID: | 55529 |
| Uniprot: | Q8N4L2 |
| Cellular Location: | Late endosome membrane, Lysosome membrane, Multi-pass membrane protein |
| Calculated MW: | 28kDa |
| Observed MW: | 28kDa |
| Synonyms: | TMEM55A |
| Background: |
| UniProt Protein Function: | TMEM55A: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 3.1.3.78; Phosphatase, lipid Chromosomal Location of Human Ortholog: 8q21.3 Cellular Component: integral to membrane; late endosome membrane; lysosomal membrane Biological Process: phosphoinositide dephosphorylation |
| NCBI Summary: | TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N4L2 |
| NCBI GenInfo Identifier: | 24308165 |
| NCBI Gene ID: | 55529 |
| NCBI Accession: | NP_061180.1 |
| UniProt Secondary Accession: | Q8N4L2,Q68CU2, B2R9H4, |
| UniProt Related Accession: | Q8N4L2 |
| Molecular Weight: | 28,081 Da |
| NCBI Full Name: | type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
| NCBI Synonym Full Names: | transmembrane protein 55A |
| NCBI Official Symbol: | TMEM55A |
| NCBI Protein Information: | type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
| UniProt Protein Name: | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
| UniProt Synonym Protein Names: | PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A |
| Protein Family: | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
| UniProt Gene Name: | TMEM55A |
| UniProt Entry Name: | TM55A_HUMAN |
 | Western blot analysis of extracts of mouse liver, using TMEM55A antibody (CAB15471) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s. |
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