Cell Biology Antibodies 3
Anti-TMEM126A Antibody (CAB12823)
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- SKU:
- CAB12823
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMEM126A Antibody |
| Antibody SKU: | CAB12823 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human TMEM126A (NP_115649.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, 22Rv1, Rat ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human TMEM126A (NP_115649.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MENH KSNN KENI TIVD ISRK INQL PEAE RNLL ENGS VYVG LNAA LCGL IANS LFRR ILNV TKAR IAAG LPMA GIPF LTTD LTYR CFVS FPLN TGDL DCET CTIT RSGL TGLV IGGL YPVF LAIP VNGG LAAR YQSA LLPH KGNI LSYW IRTS KPVF RKML FPIL LQTM FSAY LGSE QYKL LIKA LQLS EPGK EIH |
| Gene ID: | 84233 |
| Uniprot: | Q9H061 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 13kDa/21kDa |
| Observed MW: | 21kDa |
| Synonyms: | TMEM126A, OPA7 |
| Background: | The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TMEM126A: Defects in TMEM126A are the cause of optic atrophy type 7 (OPA7). A hereditary condition that features progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA7 is an autosomal recessive juvenile-onset optic atrophy characterized by severe bilateral deficiency in visual acuity, optic disk pallor, and central scotoma. Belongs to the TMEM126 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: mitochondrion Biological Process: optic nerve development Disease: Optic Atrophy 7 With Or Without Auditory Neuropathy |
| NCBI Summary: | The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9H061 |
| NCBI GenInfo Identifier: | 74733515 |
| NCBI Gene ID: | 84233 |
| NCBI Accession: | Q9H061.1 |
| UniProt Secondary Accession: | Q9H061,B2R570, E9PI16, |
| UniProt Related Accession: | Q9H061 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Transmembrane protein 126A |
| NCBI Synonym Full Names: | transmembrane protein 126A |
| NCBI Official Symbol: | TMEM126A |
| NCBI Official Synonym Symbols: | OPA7 |
| NCBI Protein Information: | transmembrane protein 126A |
| UniProt Protein Name: | Transmembrane protein 126A |
| Protein Family: | Transmembrane protein |
| UniProt Gene Name: | TMEM126A |
 | Western blot analysis of extracts of various cell lines, using TMEM126A antibody (CAB12823) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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