Anti-TMEM106B Antibody (CAB20165)
- SKU:
- CAB20165
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HLD16
Description
| Product Name: | TMEM106B Rabbit pAb |
| Product Code: | CAB20165 |
| Size: | 50uL, 100uL |
| Synonyms: | HLD16 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TMEM106B. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, Mouse liver, Mouse brain, Rat brain |
| Immunogen: | Recombinant protein of human TMEM106B. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 54664 |
| Uniprot: | Q9NUM4 |
| Calculated MW: | 42kDa |
| Observed MW: | 70KDa |
| UniProt Protein Function: | TMEM106B: TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. Belongs to the TMEM106 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p21.3Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; integral to membraneMolecular Function: protein bindingBiological Process: lysosome localization; transport; dendrite morphogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NUM4 |
| NCBI GenInfo Identifier: | 109895058 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9NUM4.2 |
| UniProt Secondary Accession: | Q9NUM4 |
| UniProt Related Accession: | Q9NUM4 |
| Molecular Weight: | |
| NCBI Full Name: | Transmembrane protein 106B |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Transmembrane protein 106B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Transmembrane protein |
| UniProt Gene Name: | TMEM106B |
| UniProt Entry Name: | T106B_HUMAN |
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