Cell Biology Antibodies 13

Anti-TMED2 Antibody (CAB17622)

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SKU:
CAB17622
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMED2 Antibody
Antibody SKU:CAB17622
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HepG2, Mouse liver, Mouse kidney, Rat spleen, Rat lung, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EITG PDNK GIYK GDRE SSGK YTFA AHMD GTYK FCFS NRMS TMTP KIVM FTID IGEA PKGQ DMET EAHQ NKLE EMIN ELAV AMTA VKHE QEYM EVRE RIHR AIND NTNS RVV
Gene ID:10959
Uniprot:Q15363
Cellular Location:
Calculated MW:22kDa
Observed MW:23kDa
Anti-TMED2 Antibody (CAB17622)Western blot - TMED2 Polyclonal Antibody (CAB17622)
Synonyms:P24A, RNP24, p24, p24b1, p24beta1, TMED2
Background:
UniProt Protein Function:TMED2: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. Belongs to the EMP24/GP25L family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: COPI-coated vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; transport vesicle; zymogen granule membrane

Molecular Function:protein binding

Biological Process: COPI coating of Golgi vesicle; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER

UniProt Code:Q15363
NCBI GenInfo Identifier:3914237
NCBI Gene ID:10959
NCBI Accession:Q15363.1
UniProt Related Accession:Q15363
Molecular Weight:22,761 Da
NCBI Full Name:Transmembrane emp24 domain-containing protein 2
NCBI Synonym Full Names:transmembrane p24 trafficking protein 2
NCBI Official Symbol:TMED2  
NCBI Official Synonym Symbols:p24; P24A; RNP24; p24b1; p24beta1  
NCBI Protein Information:transmembrane emp24 domain-containing protein 2
UniProt Protein Name:Transmembrane emp24 domain-containing protein 2
UniProt Synonym Protein Names:Membrane protein p24A; p24; p24 family protein beta-1; p24beta1
Protein Family:Transmembrane emp24 domain-containing protein
UniProt Gene Name:TMED2  
UniProt Entry Name:TMED2_HUMAN
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