Cell Biology Antibodies 12
Anti-TMED1 Antibody (CAB9963)
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- SKU:
- CAB9963
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMED1 Antibody |
| Antibody SKU: | CAB9963 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-194 of human TMED1 (NP_006849.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-194 of human TMED1 (NP_006849.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGPP PIQD GEFT FLLP AGRK QCFY QSAP ANAS LETE YQVI GGAG LDVD FTLE SPQG VLLV SESR KADG VHTV EPTE AGDY KLCF DNSF STIS EKLV FFEL IFDS LQDD EEVE GWAE AVEP EEML DVKM EDIK ESIE TMRT RLER SIQM LTLL RAFE ARDR NLQE GNLE RVN |
| Gene ID: | 11018 |
| Uniprot: | Q13445 |
| Cellular Location: | Cell membrane, Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus, Single-pass type I membrane protein, cis-Golgi network membrane |
| Calculated MW: | 25kDa |
| Observed MW: | 25kDa |
| Synonyms: | TMED1, IL1RL1LG, Il1rl1l, Tp24, p24g1 |
| Background: | This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. |
| UniProt Protein Function: | TMED1: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Belongs to the EMP24/GP25L family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: endoplasmic reticulum; ER-Golgi intermediate compartment; Golgi apparatus Molecular Function:protein binding; receptor binding Biological Process: cell-cell signaling; signal transduction |
| NCBI Summary: | This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q13445 |
| NCBI GenInfo Identifier: | 74739789 |
| NCBI Gene ID: | 11018 |
| NCBI Accession: | Q13445.1 |
| UniProt Related Accession: | Q13445 |
| Molecular Weight: | 25,206 Da |
| NCBI Full Name: | Transmembrane emp24 domain-containing protein 1 |
| NCBI Synonym Full Names: | transmembrane p24 trafficking protein 1 |
| NCBI Official Symbol: | TMED1 |
| NCBI Official Synonym Symbols: | Tp24; p24g1; Il1rl1l; IL1RL1LG |
| NCBI Protein Information: | transmembrane emp24 domain-containing protein 1 |
| UniProt Protein Name: | Transmembrane emp24 domain-containing protein 1 |
| UniProt Synonym Protein Names: | Interleukin-1 receptor-like 1 ligand; Putative T1/ST2 receptor-binding protein; p24 family protein gamma-1; Tp24; p24gamma1 |
| Protein Family: | Transmembrane emp24 domain-containing protein |
| UniProt Gene Name: | TMED1 |
| UniProt Entry Name: | TMED1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TMED1 antibody (CAB9963) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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