Cell Death Antibodies 2

Anti-TM2D1 Antibody (CAB7840)

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SKU:
CAB7840
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-TM2D1 Antibody
Antibody SKU:CAB7840
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-207 of human TM2D1 (NP_114416.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NCI-H460, HeLa, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-207 of human TM2D1 (NP_114416.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TSAG GEES LKCE DLKV GQYI CKDP KIND ATQE PVNC TNYT AHVS CFPA PNIT CKDS SGNE THFT GNEV GFFK PISC RNVN GYSY KVAV ALSL FLGW LGAD RFYL GYPA LGLL KFCT VGFC GIGS LIDF ILIS MQIV GPSD GSSY IIDY YGTR LTRL SITN ETFR KTQL YP
Gene ID:83941
Uniprot:Q9BX74
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:22kDa
Observed MW:30kDa
Synonyms:TM2D1, BBP
Background:The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene.
UniProt Protein Function:TM2D1: May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42. Belongs to the TM2 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: nucleoplasm; integral to plasma membrane

Molecular Function:G-protein coupled receptor activity; beta-amyloid binding

Biological Process: G-protein coupled receptor protein signaling pathway

UniProt Code:Q9BX74
NCBI GenInfo Identifier:14042945
NCBI Gene ID:
NCBI Accession:NP_114416.1
Molecular Weight:~ 22kDa
NCBI Full Name:TM2 domain-containing protein 1
UniProt Protein Name:TM2 domain-containing protein 1
UniProt Synonym Protein Names:Beta-amyloid-binding protein; hBBP
Protein Family:Branchpoint-bridging protein
UniProt Gene Name:TM2D1  
UniProt Entry Name:TM2D1_HUMAN
Anti-TM2D1 Antibody (CAB7840)Western blot analysis of extracts of various cell lines, using TM2D1 antibody (CAB7840) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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