Cell Biology Antibodies 3

Anti-TLX1 Antibody (CAB12861)

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SKU:
CAB12861
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TLX1 Antibody
Antibody SKU:CAB12861
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_001182446.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, K562, Mouse spleen, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_001182446.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEHL GPHH LHPG HAEP ISFG IDQI LNSP DQGG CMGP ASRL QDGE YGLG CLVG GAYT YGGG GSAA ATGA GGAG AYGT GGPG GPGG PAGG GGAC SMGP LTGS YNVN MALA GGPG PGGG GGSS GGAG ALSA AGVI RVPA HRPL AGAV AHPQ PLAT GLPT VPSV PAMP GVNN LTGL TFPW MESN RRYT KDRF TG
Gene ID:3195
Uniprot:P31314
Cellular Location:Nucleus
Calculated MW:26kDa/34kDa
Observed MW:40kDa
Synonyms:TLX1, HOX11, TCL3
Background:This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleus

Molecular Function:protein binding; protein heterodimerization activity; sequence-specific DNA binding

Biological Process: spleen development; neuron differentiation; organ formation; central nervous system development; cell fate commitment; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Code:P31314
NCBI GenInfo Identifier:399982
NCBI Gene ID:3195
NCBI Accession:P31314.1
UniProt Secondary Accession:P31314,O75699, Q5VXP2, Q9HCA0, Q9UD59, A1L4G3,
UniProt Related Accession:P31314
Molecular Weight:26,245 Da
NCBI Full Name:T-cell leukemia homeobox protein 1
NCBI Synonym Full Names:T-cell leukemia homeobox 1
NCBI Official Symbol:TLX1  
NCBI Official Synonym Symbols:TCL3; HOX11  
NCBI Protein Information:T-cell leukemia homeobox protein 1; proto-oncogene TCL-3; homeobox protein Hox-11; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
UniProt Protein Name:T-cell leukemia homeobox protein 1
UniProt Synonym Protein Names:Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3
Protein Family:T-cell leukemia homeobox protein
UniProt Gene Name:TLX1  
UniProt Entry Name:TLX1_HUMAN
Anti-TLX1 Antibody (CAB12861)Western blot analysis of extracts of various cell lines, using TLX1 antibody (CAB12861) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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