Cell Biology Antibodies 15

Anti-TLR6 Antibody (CAB8185)

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SKU:
CAB8185
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody

Description

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Antibody Name:Anti-TLR6 Antibody
Antibody SKU:CAB8185
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human TLR6 (NP_006059.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human TLR6 (NP_006059.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NEFA VDKS KRGL IHVP KDLP LKTK VLDM SQNY IAEL QVSD MSFL SELT VLRL SHNR IQLL DLSV FKFN QDLE YLDL SHNQ LQKI SCHP IVSF RHLD LSFN DFKA LPIC KEFG NLSQ LNFL GLSA MKLQ KLDL LPIA HLHL SYIL LDLR NYYI KENE TESL QILN AKTL H
Gene ID:10333
Uniprot:Q9Y2C9
Cellular Location:Cell membrane, Cytoplasmic vesicle, Single-pass type I membrane protein, phagosome membrane
Calculated MW:55kDa/91kDa
Observed MW:Refer to figures
Synonyms:TLR6, CD286
Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
UniProt Protein Function:TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; phagocytic vesicle membrane; plasma membrane

Molecular Function:protein binding; receptor activity; transmembrane receptor activity

Biological Process: activation of NF-kappaB-inducing kinase; defense response to bacterium; detection of diacylated bacterial lipoprotein; immune response; inflammatory response; innate immune response; interleukin-1 beta secretion; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; regulation of cytokine secretion; signal transduction; T-helper 1 type immune response; toll-like receptor 6 signaling pathway; toll-like receptor signaling pathway

NCBI Summary:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
UniProt Code:Q9Y2C9
NCBI GenInfo Identifier:296452933
NCBI Gene ID:10333
NCBI Accession:Q9Y2C9.2
UniProt Secondary Accession:Q9Y2C9,Q2NKL3, B3Y640, B6CH35, B6RFS4, B6RFS5,
UniProt Related Accession:Q9Y2C9
Molecular Weight:55,828 Da
NCBI Full Name:Toll-like receptor 6
NCBI Synonym Full Names:toll like receptor 6
NCBI Official Symbol:TLR6  
NCBI Official Synonym Symbols:CD286  
NCBI Protein Information:toll-like receptor 6
UniProt Protein Name:Toll-like receptor 6
UniProt Synonym Protein Names:CD_antigen: CD286
UniProt Gene Name:TLR6  
UniProt Entry Name:TLR6_HUMAN
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