Name: Anti-TLR10 Antibody (CAB5852)
Brand: Immunology Antibodies 2
SKU: CAB5852
Availability: OutOfStock

Antibody Name:	Anti-TLR10 Antibody
Antibody SKU:	CAB5852
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human TLR10 (NP_001182036.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HL-60, HepG2, 293T, Mouse spleen, Mouse thymus

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human TLR10 (NP_001182036.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	DAPE LPEE RELM TNCS NMSL RKVP ADLT PATT TLDL SYNL LFQL QSSD FHSV SKLR VLIL CHNR IQQL DLKT FEFN KELR YLDL SNNR LKSV TWYL LAGL RYLD LSFN DFDT MPIC EEAG NMSH LEIL GLSG AKIQ KSDF QKIA HLHL NTVF LGFR TLPH YEEG SLPI LNTT KLHI VLPM DTNF WVLL RDGI KTSK ILEM TNID GKSQ FVSY EMQR NLSL ENAK TSVL LLNK VDLL WDDL FLIL QFVW HTS
Gene ID:	81793
Uniprot:	Q9BXR5
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	94kDa
Observed MW:	95kDa

Synonyms:

TLR10, CD290

Background:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.

UniProt Protein Function:	TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 4p14 Cellular Component: membrane; integral to membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 10 signaling pathway; positive regulation of inflammatory response
NCBI Summary:	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Code:	Q9BXR5
NCBI GenInfo Identifier:	116242819
NCBI Gene ID:	81793
NCBI Accession:	Q9BXR5.2
UniProt Secondary Accession:	Q9BXR5,Q32MI7, Q32MI8, Q5FWG4, Q6UXL3, A8K7L1, B3Y668 D1CS21, D1CS22,
UniProt Related Accession:	Q9BXR5
Molecular Weight:	94,564 Da
NCBI Full Name:	Toll-like receptor 10
NCBI Synonym Full Names:	toll-like receptor 10
NCBI Official Symbol:	TLR10
NCBI Official Synonym Symbols:	CD290
NCBI Protein Information:	toll-like receptor 10
UniProt Protein Name:	Toll-like receptor 10
UniProt Synonym Protein Names:	CD_antigen: CD290
Protein Family:	Toll-like receptor
UniProt Gene Name:	TLR10
UniProt Entry Name:	TLR10_HUMAN

Western blot analysis of extracts of various cell lines, using TLR10 antibody (CAB5852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 50s.

ELISA Kits

Human Toll-like receptor 10 (TLR10) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)