Cell Cycle Antibodies 1
Anti-TLK1 Antibody (CAB14831)
- SKU:
- CAB14831
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Antibody Name: | Anti-TLK1 Antibody |
Antibody SKU: | CAB14831 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-230 of human TLK1 (NP_036422.3). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | LO2, 293T, BxPC-3, HeLa, Jurkat, Mouse testis, Mouse pancreas, Rat testis |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-230 of human TLK1 (NP_036422.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | PVRG IPPA IRSP QNSH SHST PSSS VRPN SPSP TALA FGDH PIVQ PKQL SFKI IQTD LTML KLAA LESN KIQ |
Gene ID: | 9874 |
Uniprot: | Q9UKI8 |
Cellular Location: | Nucleus |
Calculated MW: | 63kDa/77kDa/81kDa/86kDa/89kDa |
Observed MW: | 80kDa |
Synonyms: | TLK1, PKU-beta |
Background: | The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
NCBI Summary: | The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | Q9UKI8 |
NCBI GenInfo Identifier: | 34223086 |
NCBI Gene ID: | 9874 |
NCBI Accession: | Q9UKI8.2 |
UniProt Secondary Accession: | Q9UKI8,Q14150, Q8N591, Q9NYH2, Q9Y4F6, B3KR15, B4DX87 |
UniProt Related Accession: | Q9UKI8 |
Molecular Weight: | 81,927 Da |
NCBI Full Name: | Serine/threonine-protein kinase tousled-like 1 |
NCBI Synonym Full Names: | tousled like kinase 1 |
NCBI Official Symbol: | TLK1 |
NCBI Official Synonym Symbols: | PKU-beta |
NCBI Protein Information: | serine/threonine-protein kinase tousled-like 1 |
UniProt Protein Name: | Serine/threonine-protein kinase tousled-like 1 |
UniProt Synonym Protein Names: | PKU-beta; Tousled-like kinase 1 |
Protein Family: | Serine/threonine-protein kinase tousled |
UniProt Gene Name: | TLK1 |
UniProt Entry Name: | TLK1_HUMAN |
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