Cell Biology Antibodies 13
Anti-TLE3 Antibody (CAB17539)
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- SKU:
- CAB17539
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TLE3 Antibody |
| Antibody SKU: | CAB17539 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-240 of human TLE3 (NP_005069.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-240 of human TLE3 (NP_005069.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PVTG SSSG LLAL GALG SQAH LTVK DEKN HHEL DHRE RESS ANNS VSPS ESLR ASEK HRGS ADYS MEAK KRKA EEKD SLSR YDS |
| Gene ID: | 7090 |
| Uniprot: | Q04726 |
| Cellular Location: | |
| Calculated MW: | 82kDa/83kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ESG, ESG3, GRG3, HsT18976, TLE3 |
| Background: | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] |
| UniProt Protein Function: | TLE3: transcriptional corepressor that binds to a number of transcription factors. Belongs to the WD-repeat Groucho/TLE family. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q22 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: Notch signaling pathway; organ morphogenesis; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; signal transduction |
| NCBI Summary: | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q04726 |
| NCBI GenInfo Identifier: | 20532417 |
| NCBI Gene ID: | 7090 |
| NCBI Accession: | Q04726.2 |
| UniProt Related Accession: | Q04726 |
| Molecular Weight: | 82kDa; 83kDa |
| NCBI Full Name: | Transducin-like enhancer protein 3 |
| NCBI Synonym Full Names: | TLE family member 3, transcriptional corepressor |
| NCBI Official Symbol: | TLE3 |
| NCBI Official Synonym Symbols: | ESG; ESG3; GRG3; HsT18976 |
| NCBI Protein Information: | transducin-like enhancer protein 3 |
| UniProt Protein Name: | Transducin-like enhancer protein 3 |
| UniProt Synonym Protein Names: | Enhancer of split groucho-like protein 3; ESG3 |
| Protein Family: | Transducin-like enhancer protein |
| UniProt Gene Name: | TLE3 |
| UniProt Entry Name: | TLE3_HUMAN |
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