Cell Cycle Antibodies 1

Anti-TIPIN Antibody (CAB10344)

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SKU:
CAB10344
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-TIPIN Antibody
Antibody SKU:CAB10344
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human TIPIN (NP_060328.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, HeLa, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human TIPIN (NP_060328.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLEP QENG VIDL PDYE HVED ETFP PFPP PASP ERQD GEGT EPDE ESGN GAPV PVPP KRTV KRNI PKLD AQRL ISER GLPA LRHV FDKA KFKG KGHE AEDL KMLI RHME HWAH RLFP KLQF EDFI DRVE YLGS KKEV QTCL KRIR LDLP ILHE DFVS NNDE VAEN NEHD VTST ELDP FLTN LSES EMFA SELS RSLT EEQQ QRIE RNKQ LALE RRQA KLLS NSQT LGND MLMN TPRA HTVE EVNT DEDQ KEES NGLN EDIL DNPC NDAI ANTL NEEE TLLD QSFK NVQQ QLDA TSRN ITEA R
Gene ID:54962
Uniprot:Q9BVW5
Cellular Location:Cytoplasm, Nucleus
Calculated MW:34kDa
Observed MW:50kDa
Synonyms:TIPIN
Background:The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TIPIN: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Belongs to the CSM3 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: intracellular membrane-bound organelle; nuclear chromatin; nucleoplasm; nucleus

Molecular Function:DNA binding; protein binding

Biological Process: DNA replication; DNA replication checkpoint; intra-S DNA damage checkpoint; positive regulation of cell proliferation; regulation of DNA replication during S phase; replication fork arrest; replication fork protection

NCBI Summary:The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:Q9BVW5
NCBI GenInfo Identifier:296452932
NCBI Gene ID:54962
NCBI Accession:Q9BVW5.2
UniProt Secondary Accession:Q9BVW5,Q9NWZ6, B2CW64,
UniProt Related Accession:Q9BVW5
Molecular Weight:35kDa
NCBI Full Name:TIMELESS-interacting protein
NCBI Synonym Full Names:TIMELESS interacting protein
NCBI Official Symbol:TIPIN  
NCBI Protein Information:TIMELESS-interacting protein
UniProt Protein Name:TIMELESS-interacting protein
Protein Family:TIMELESS-interacting protein
UniProt Gene Name:TIPIN  
Anti-TIPIN Antibody (CAB10344)Western blot analysis of extracts of various cell lines, using TIPIN antibody (CAB10344) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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