Cell Biology Antibodies 13

Anti-TINAG Antibody (CAB17688)

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SKU:
CAB17688
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TINAG Antibody
Antibody SKU:CAB17688
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human TINAG (NP_055279.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human TINAG (NP_055279.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AIFQ GQYC RNFG CCED RDDG CVTE FYAA NALC YCDK FCDR ENSD CCPD YKSF CREE KEWP PHTQ PWYP EGCF KDGQ HYEE GSVI KENC NSCT CSGQ QWKC SQHV CLVR SELI EQVN KGDY GWTA QNYS QFWG MTLE DGFK FRLG TLPP SPML LSMN EMTA SLPA TTDL PEFF VASY KWPG WTHG PLDQ KNC
Gene ID:27283
Uniprot:Q9UJW2
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:TIN-AG, TINAG
Background:This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
UniProt Protein Function:TINAG: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: basement membrane

Molecular Function:cysteine-type endopeptidase activity; nucleotide binding; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; immune response; proteolysis; cell adhesion

NCBI Summary:This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
UniProt Code:Q9UJW2
NCBI GenInfo Identifier:224586907
NCBI Gene ID:27283
NCBI Accession:NP_055279.3
UniProt Secondary Accession:Q9UJW2,Q5T467, Q9UJW1, Q9ULZ4,
UniProt Related Accession:Q9UJW2
Molecular Weight:38,724 Da
NCBI Full Name:tubulointerstitial nephritis antigen
NCBI Synonym Full Names:tubulointerstitial nephritis antigen
NCBI Official Symbol:TINAG  
NCBI Official Synonym Symbols:TIN-AG  
NCBI Protein Information:tubulointerstitial nephritis antigen
UniProt Protein Name:Tubulointerstitial nephritis antigen
UniProt Gene Name:TINAG  
UniProt Entry Name:TINAG_HUMAN
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