Anti-Timp1 Antibody (MACO0526)
- SKU:
- MACO0526
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Mouse
- Isotype:
- IgG1
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
| Product Name: | Anti-Timp1 Antibody |
| Product Sku: | MACO0526 |
| Size: | 50ug |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:50-1:500 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Timp1 |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%,Protein G purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity. |
| Synonyms: | Timp-1 |
 | Immunohistochemistry of paraffin-embedded Rat prostate cancer using MACO0526 at dilution of 1:100. |
| UniProt Protein Function: | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity. |
| NCBI Summary: | acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006] |
| UniProt Code: | P30120 |
| NCBI GenInfo Identifier: | 1174697 |
| NCBI Gene ID: | 116510 |
| NCBI Accession: | P30120.2 |
| UniProt Secondary Accession: | P30120,P70533, Q53YM7, |
| UniProt Related Accession: | P30120 |
| Molecular Weight: | 23,794 Da |
| NCBI Full Name: | Metalloproteinase inhibitor 1 |
| NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 1 |
| NCBI Official Symbol: | Timp1 |
| NCBI Official Synonym Symbols: | Timp; TIMP-1 |
| NCBI Protein Information: | metalloproteinase inhibitor 1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1 |
| UniProt Protein Name: | Metalloproteinase inhibitor 1 |
| UniProt Synonym Protein Names: | Tissue inhibitor of metalloproteinases 1; TIMP-1 |
| Protein Family: | Metalloproteinase inhibitor |
| UniProt Gene Name: | Timp1 |
| UniProt Entry Name: | TIMP1_RAT |
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