Immunology Antibodies 1
Anti-TIM-3/HAVCR2 Antibody (CAB13445)
(No reviews yet)
Write a Review
- SKU:
- CAB13445
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TIM-3/HAVCR2 Antibody |
| Antibody SKU: | CAB13445 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-202 of human TIM-3/HAVCR2 (NP_116171.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Mouse spleen, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-202 of human TIM-3/HAVCR2 (NP_116171.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEVE YRAE VGQN AYLP CFYT PAAP GNLV PVCW GKGA CPVF ECGN VVLR TDER DVNY WTSR YWLN GDFR KGDV SLTI ENVT LADS GIYC CRIQ IPGI MNDE KFNL KLVI KPAK VTPA PTRQ RDFT AAFP RMLT TRGH GPAE TQTL GSLP DINL TQIS TLAN ELRD SRLA NDLR DSGA TIRI G |
| Gene ID: | 84868 |
| Uniprot: | Q8TDQ0 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 16kDa/33kDa |
| Observed MW: | 50kDa |
| Synonyms: | HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 |
| Background: | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. |
| UniProt Protein Function: | TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: integral to membrane Disease: Rheumatoid Arthritis |
| NCBI Summary: | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q8TDQ0 |
| NCBI GenInfo Identifier: | 311033536 |
| NCBI Gene ID: | 84868 |
| NCBI Accession: | Q8TDQ0.3 |
| UniProt Related Accession: | Q8TDQ0 |
| Molecular Weight: | |
| NCBI Full Name: | Hepatitis A virus cellular receptor 2 |
| NCBI Synonym Full Names: | hepatitis A virus cellular receptor 2 |
| NCBI Official Symbol: | HAVCR2 |
| NCBI Official Synonym Symbols: | TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2 |
| NCBI Protein Information: | hepatitis A virus cellular receptor 2 |
| UniProt Protein Name: | Hepatitis A virus cellular receptor 2 |
| UniProt Synonym Protein Names: | T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3 |
| UniProt Gene Name: | HAVCR2 |
| UniProt Entry Name: | HAVR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TIM-3/HAVCR2 antibody (CAB13445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose
Related Products
Anti-HAVCR2 Antibody (CAB20495)
OverviewProduct Name:HAVCR2 Rabbit pAbProduct Code:CAB20495Size:50uL, 100uLSynonyms:Tim, TIM-, Tim3, Timd, TIM-3, Timd3