Anti-TIGAR Antibody (CAB20416)
- SKU:
- CAB20416
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- FR2BP
- Synonyms:
- C12orf5
Description
| Product Name: | TIGAR Rabbit pAb |
| Product Code: | CAB20416 |
| Size: | 50uL, 100uL |
| Synonyms: | FR2BP, C12orf5 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TIGAR. |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | Recombinant protein of human TIGAR. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 57103 |
| Uniprot: | Q9NQ88 |
| Calculated MW: | 30kDa |
| Observed MW: | 30kDa |
| UniProt Protein Function: | TIGAR: Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. Belongs to the phosphoglycerate mutase family. Protein type: EC 3.1.3.46; Phosphatase (non-protein) Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytoplasm; cytosol; intracellular; mitochondrial outer membrane; nucleus Molecular Function: bisphosphoglycerate phosphatase activity; fructose-2,6-bisphosphate 2-phosphatase activity; protein binding Biological Process: apoptosis; autophagy; dephosphorylation; fructose 1,6-bisphosphate metabolic process; fructose 2,6-bisphosphate metabolic process; gene expression; negative regulation of glycolysis; negative regulation of programmed cell death; positive regulation of DNA repair; regulation of pentose-phosphate shunt; response to DNA damage stimulus; response to gamma radiation; response to xenobiotic stimulus; transcription initiation from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQ88 |
| NCBI GenInfo Identifier: | 74734311 |
| NCBI Gene ID: | 57103 |
| NCBI Accession: | Q9NQ88.1 |
| UniProt Secondary Accession: | Q9NQ88,B2R840 |
| UniProt Related Accession: | Q9NQ88 |
| Molecular Weight: | 30,063 Da |
| NCBI Full Name: | Fructose-2,6-bisphosphatase TIGAR |
| NCBI Synonym Full Names: | TP53 induced glycolysis regulatory phosphatase |
| NCBI Official Symbol: | TIGAR |
| NCBI Official Synonym Symbols: | FR2BP; C12orf5 |
| NCBI Protein Information: | fructose-2,6-bisphosphatase TIGAR |
| UniProt Protein Name: | Fructose-2,6-bisphosphatase TIGAR |
| UniProt Synonym Protein Names: | TP53-induced glycolysis and apoptosis regulator |
| Protein Family: | Fructose-2,6-bisphosphatase |
| UniProt Gene Name: | TIGAR |
| UniProt Entry Name: | TIGAR_HUMAN |
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