Immunology Antibodies 3

Anti-TICAM2 Antibody (CAB8292)

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SKU:
CAB8292
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:TICAM2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8292
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human TICAM2 (NP_067681.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:22Rv1, 293T, Jurkat, Raji, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human TICAM2 (NP_067681.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGIG KSKI NSCP LSLS WGKR HSVD TSPG YHES DSKK SEDL SLCN VAEH SNTT EGPT GKQE GAQS VEEM FEEE AEEE VFLK FVIL HAED DTDE ALRV QNLL QDDF GIKP GIIF AEMP CGRQ HLQN LDDA VNGS AWTI LLLT ENFL RDTW CNFQ FYTS LMNS VNRQ HKYN SVIP MRPL NNPL PRER TPFA LQTI NALE EESR GFPT QVER IFQE SVYK TQQT IWKE TRNM VQRQ FIA
Gene ID:353376
Uniprot:Q86XR7
Cellular Location:Cell membrane, Cytoplasm, Early endosome membrane, Endoplasmic reticulum, Golgi apparatus, Late endosome membrane, Late endosome membrane
Calculated MW:26kDa/46kDa
Observed MW:37kDa
Synonyms:TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
Background:
UniProt Protein Function:Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
NCBI Summary:This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
UniProt Code:Q86XR7
NCBI GenInfo Identifier:74727858
NCBI Gene ID:100302736
NCBI Accession:Q86XR7.1
UniProt Secondary Accession:Q86XR7,Q6JUT2, B3Y698,
Molecular Weight:46,173 Da
NCBI Full Name:TIR domain-containing adapter molecule 2
NCBI Synonym Full Names:TMED7-TICAM2 readthrough
NCBI Official Symbol:TMED7-TICAM2  
NCBI Protein Information:TRAM adaptor with GOLD domain
UniProt Protein Name:TIR domain-containing adapter molecule 2
UniProt Synonym Protein Names:Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
Protein Family:TIR domain-containing adapter molecule
UniProt Gene Name:TICAM2  
UniProt Entry Name:TCAM2_HUMAN
Anti-TICAM2 Polyclonal Antibody (CAB8292)Western blot analysis of extracts of various cell lines, using TICAM2 antibody (CAB8292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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