Epigenetics & Nuclear Signaling Antibodies 2
Anti-THRA Antibody (CAB5592)
- SKU:
- CAB5592
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-THRA Antibody |
| Antibody SKU: | CAB5592 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human THRA (NP_003241.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human THRA (NP_003241.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DKIT RNQC QLCR FKKC IAVG MAMD LVLD DSKR VAKR KLIE QNRE RRRK EEMI RSLQ QRPE PTPE EWDL IHIA TEAH RSTN AQGS HWKQ RRKF LPDD IGQS P |
| Gene ID: | 7067 |
| Uniprot: | P10827 |
| Cellular Location: | Nucleus |
| Calculated MW: | 46kDa/50kDa/54kDa |
| Observed MW: | 55KDa |
| Synonyms: | THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1 |
| Background: | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| UniProt Protein Function: | TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor; Transcription factor Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: nucleoplasm; cytosol; nucleus Molecular Function:protein domain specific binding; protein binding; zinc ion binding; sequence-specific DNA binding; TATA-binding protein binding; chromatin DNA binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; ossification; cytoplasmic sequestering of transcription factor; intracellular receptor-mediated signaling pathway; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of lipid catabolic process; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; female courtship behavior; learning and/or memory; thyroid gland development; erythrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of transcription, DNA-dependent; cartilage condensation Disease: Hypothyroidism, Congenital, Nongoitrous, 6 |
| NCBI Summary: | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10827 |
| NCBI GenInfo Identifier: | 135705 |
| NCBI Gene ID: | 7067 |
| NCBI Accession: | P10827.1 |
| UniProt Secondary Accession: | P10827,P21205, Q8N6A1, Q96H73, A8K3B5, |
| UniProt Related Accession: | P10827 |
| Molecular Weight: | 50,465 Da |
| NCBI Full Name: | Thyroid hormone receptor alpha |
| NCBI Synonym Full Names: | thyroid hormone receptor, alpha |
| NCBI Official Symbol: | THRA |
| NCBI Official Synonym Symbols: | AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1 |
| NCBI Protein Information: | thyroid hormone receptor alpha; EAR-7; c-erbA-alpha; ERBA-related 7; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) |
| UniProt Protein Name: | Thyroid hormone receptor alpha |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha |
| Protein Family: | Thyroid hormone receptor |
| UniProt Gene Name: | THRA |
| UniProt Entry Name: | THA_HUMAN |
 | Western blot analysis of extracts of SH-SY5Y cells, using THRA antibody (CAB5592) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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