Cell Biology Antibodies 12
Anti-THOP1 Antibody (CAB8756)
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- SKU:
- CAB8756
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-THOP1 Antibody |
| Antibody SKU: | CAB8756 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Mouse heart, Mouse lung, Rat liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKPP AACA GDMA DAAS PCSV VNDL RWDL SAQQ IEER TREL IEQT KRVY DQVG TQEF EDVS YEST LKAL ADVE VTYT VQRN ILDF PQHV SPSK DIRT ASTE ADKK LSEF DVEM SMRE DVYQ RIVW LQEK VQKD SLRP EAAR YLER LIKL GRRN GLHL PRET QENI KRIK KKLS LLCI DFNK NLNE DTTF LPFT LQEL GGLP EDFL NSLE KMED GKLK VTLK YPHY FPLL KKCH VPET RRKV EEAF NCRC KEEN CAIL KELV |
| Gene ID: | 7064 |
| Uniprot: | P52888 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 28kDa/78kDa |
| Observed MW: | 79kDa |
| Synonyms: | THOP1, EP24.15, MEPD_HUMAN, MP78, TOP |
| Background: | The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. |
| NCBI Summary: | The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P52888 |
| NCBI GenInfo Identifier: | 33878319 |
| NCBI Gene ID: | 7064 |
| NCBI Accession: | BC013878 |
| UniProt Secondary Accession: | P52888,Q9UCB3, B3KSE2, |
| UniProt Related Accession: | P52888 |
| Molecular Weight: | 28,908 Da |
| NCBI Full Name: | Homo sapiens thimet oligopeptidase 1, mRNA |
| NCBI Synonym Full Names: | thimet oligopeptidase 1 |
| NCBI Official Symbol: | THOP1 |
| NCBI Official Synonym Symbols: | TOP; MP78; EP24.15; MEPD_HUMAN |
| NCBI Protein Information: | thimet oligopeptidase |
| UniProt Protein Name: | Thimet oligopeptidase |
| UniProt Synonym Protein Names: | Endopeptidase 24.15; MP78 |
| Protein Family: | Thimet oligopeptidase |
| UniProt Gene Name: | THOP1 |
| UniProt Entry Name: | THOP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THOP1 antibody (CAB8756) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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