Epigenetics & Nuclear Signaling Antibodies 1
Anti-THOC7 Antibody (CAB13700)
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- SKU:
- CAB13700
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-THOC7 Antibody |
| Antibody SKU: | CAB13700 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human THOC7 (NP_079351.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, A-431, 293T, Jurkat, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human THOC7 (NP_079351.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGAV TDDE VIRK RLLI DGDG AGDD RRIN LLVK SFIK WCNS GSQE EGYS QYQR MLST LSQC EFSM GKTL LVYD MNLR EMEN YEKI YKEI ECSI AGAH EKIA ECKK QILQ AKRI RKNR QEYD ALAK VIQH HPDR HETL KELE ALGK ELEH LSHI KESV EDKL ELRR KQFH VLLS TIHE LQQT LEND EKLS EVEE AQEA SMET DPKP |
| Gene ID: | 80145 |
| Uniprot: | Q6I9Y2 |
| Cellular Location: | Cytoplasm, Nucleus, Nucleus speckle |
| Calculated MW: | 23kDa |
| Observed MW: | 24kDa |
| Synonyms: | THOC7, NIF3L1BP1, fSAP24, hTREX30 |
| Background: |
| UniProt Protein Function: | THOC7: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the THOC7 family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:nucleic acid binding; protein binding Biological Process: intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; termination of RNA polymerase II transcription |
| UniProt Code: | Q6I9Y2 |
| NCBI GenInfo Identifier: | 229462996 |
| NCBI Gene ID: | 80145 |
| NCBI Accession: | Q6I9Y2.3 |
| UniProt Secondary Accession: | Q6I9Y2,Q6P1L3, Q8WUF2, Q9H5H0, |
| UniProt Related Accession: | Q6I9Y2 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | THO complex subunit 7 homolog |
| NCBI Synonym Full Names: | THO complex 7 |
| NCBI Official Symbol: | THOC7 |
| NCBI Official Synonym Symbols: | fSAP24; hTREX30; NIF3L1BP1 |
| NCBI Protein Information: | THO complex subunit 7 homolog |
| UniProt Protein Name: | THO complex subunit 7 homolog |
| UniProt Synonym Protein Names: | Functional spliceosome-associated protein 24; fSAP24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; hTREX30 |
| Protein Family: | THO complex |
| UniProt Gene Name: | THOC7 |
| UniProt Entry Name: | THOC7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THOC7 antibody (CAB13700) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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