Cell Biology Antibodies 7
Anti-THBS4 Antibody (CAB16438)
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- SKU:
- CAB16438
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-THBS4 Antibody |
| Antibody SKU: | CAB16438 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-300 of human THBS4 (NP_003239.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-300 of human THBS4 (NP_003239.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TPQV FDLL PSSS QRLN PGAL LPVL TDPA LNDL YVIS TFKL QTKS SATI FGLY SSTD NSKY FEFT VMGR LNKA ILRY LKND GKVH LVVF NNLQ LADG RRHR ILLR LSNL QRGA GSLE LYLD CIQV DSVH NLPR AFAG PSQK PETI ELRT FQRK PQDF LEEL KLVV RGSL FQVA SLQD CFLQ QSEP LAAT GTGD FNRQ FLGQ MTQL NQLL GEVK DLLR QQVK ETSF LRNT IAEC QACG PLKF QSPT PSTV VPPA PPAP PTRP PRRC DSNP CFRG VQ |
| Gene ID: | 7060 |
| Uniprot: | P35443 |
| Cellular Location: | Endoplasmic reticulum, Sarcoplasmic reticulum, Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 105kDa |
| Observed MW: | 106kDa |
| Synonyms: | THBS4, TSP-4, TSP4 |
| Background: | The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | THBS4: Acts as an extracellular mitogen and stimulates early erythroid progenitors proliferation in presence of EPO. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Belongs to the thrombospondin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q13 Cellular Component: basement membrane; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; neuromuscular junction; sarcoplasmic reticulum Molecular Function:calcium ion binding; collagen binding; fibronectin binding; growth factor activity; heparin binding; integrin binding; laminin-1 binding; protein binding Biological Process: behavioral response to pain; myoblast migration; negative regulation of angiogenesis; neurite morphogenesis; positive regulation of cell division; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; protein homooligomerization; regulation of tissue remodeling; response to unfolded protein; tissue remodeling |
| NCBI Summary: | The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | P35443 |
| NCBI GenInfo Identifier: | 55977790 |
| NCBI Gene ID: | 7060 |
| NCBI Accession: | P35443.2 |
| UniProt Secondary Accession: | P35443,Q86TG2, B2R909, |
| UniProt Related Accession: | P35443 |
| Molecular Weight: | |
| NCBI Full Name: | Thrombospondin-4 |
| NCBI Synonym Full Names: | thrombospondin 4 |
| NCBI Official Symbol: | THBS4 |
| NCBI Official Synonym Symbols: | TSP4; TSP-4 |
| NCBI Protein Information: | thrombospondin-4 |
| UniProt Protein Name: | Thrombospondin-4 |
| Protein Family: | Thrombospondin |
| UniProt Gene Name: | THBS4 |
| UniProt Entry Name: | TSP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using THBS4 antibody (CAB16438) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 150s. |
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