Cell Biology Antibodies 1

Anti-TGM2 Antibody (CAB0981)

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SKU:
CAB0981
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TGM2 Antibody
Antibody SKU:CAB0981
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human TGM2
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW480, A-549, DU145, PC-3
Immunogen:Recombinant protein of human TGM2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7052
Uniprot:P21980
Cellular Location:
Calculated MW:38kDa/61kDa/77kDa
Observed MW:90kDa
Synonyms:TGM2, TG(C), TGC
Background:Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis.. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytosol; focal adhesion; intrinsic to plasma membrane; mitochondrion

Molecular Function:protein binding; protein-glutamine gamma-glutamyltransferase activity

Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration

NCBI Summary:Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P21980
NCBI GenInfo Identifier:20141877
NCBI Gene ID:7052
NCBI Accession:P21980.2
UniProt Secondary Accession:P21980,Q16436, Q6B838, Q9BTN7, Q9UH35, E1P5V9,
UniProt Related Accession:P21980
Molecular Weight:38,671 Da
NCBI Full Name:Protein-glutamine gamma-glutamyltransferase 2
NCBI Synonym Full Names:transglutaminase 2
NCBI Official Symbol:TGM2  
NCBI Official Synonym Symbols:TGC; TG(C)  
NCBI Protein Information:protein-glutamine gamma-glutamyltransferase 2
UniProt Protein Name:Protein-glutamine gamma-glutamyltransferase 2
UniProt Synonym Protein Names:Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
Protein Family:Protein-glutamine gamma-glutamyltransferase
UniProt Gene Name:TGM2  
UniProt Entry Name:TGM2_HUMAN
Anti-TGM2 Antibody (CAB0981)Western blot analysis of extracts of various cell lines, using TGM2 antibody (CAB0981) at 1:300 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-TGM2 Antibody (CAB0981)Immunohistochemistry of paraffin-embedded mouse brain using TGM2 antibody (CAB0981) (40x lens).
Anti-TGM2 Antibody (CAB0981)Immunohistochemistry of paraffin-embedded human lung cancer using TGM2 antibody (CAB0981) (40x lens).
Anti-TGM2 Antibody (CAB0981)Immunohistochemistry of paraffin-embedded human esophagus using TGM2 antibody (CAB0981) (40x lens).
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