Cell Biology Antibodies 4

Anti-TGFBRAP1 Antibody (CAB14386)

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SKU:
CAB14386
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TGFBRAP1 Antibody
Antibody SKU:CAB14386
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 621-860 of human TGFBRAP1 (NP_004248.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, HeLa, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 621-860 of human TGFBRAP1 (NP_004248.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLQR ASAS GKGA EATE TQAK LRRL LQKS DLYR VHFL LERL QGAG LPME SAIL HGKL GEHE KALH ILVH ELQD FAAA EDYC LWCS EGRD PPHR QQLF HTLL AIYL HAGP TAHE LAVA AVDL LNRH ATEF DAAQ VLQM LPDT WSVQ LLCP FLMG AMRD SIHA RRTM QVAL GLAR SENL IYTY DKMK LKGS SIQL SDKK LCQI CQNP FCEP VFVR YPNG GLVH THCA ASRH TNPS SSSP GTRT
Gene ID:9392
Uniprot:Q8WUH2
Cellular Location:Cytoplasm, Early endosome
Calculated MW:97kDa
Observed MW:97kDa
Synonyms:TGFBRAP1, TRAP-1, TRAP1, VPS3
Background:This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes.
UniProt Protein Function:TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q12.1

Cellular Component: early endosome; membrane

Molecular Function:protein binding; SMAD binding; transforming growth factor beta receptor binding

Biological Process: endosomal vesicle fusion; endosome to lysosome transport; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway

NCBI Summary:This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]
UniProt Code:Q8WUH2
NCBI GenInfo Identifier:74730711
NCBI Gene ID:9392
NCBI Accession:Q8WUH2.1
UniProt Secondary Accession:Q8WUH2,O60466, A8K5R7, D3DVJ8,
UniProt Related Accession:Q8WUH2
Molecular Weight:97,158 Da
NCBI Full Name:Transforming growth factor-beta receptor-associated protein 1
NCBI Synonym Full Names:transforming growth factor beta receptor associated protein 1
NCBI Official Symbol:TGFBRAP1  
NCBI Official Synonym Symbols:VPS3; TRAP1; TRAP-1  
NCBI Protein Information:transforming growth factor-beta receptor-associated protein 1
UniProt Protein Name:Transforming growth factor-beta receptor-associated protein 1
Protein Family:Transforming growth factor-beta receptor-associated protein
UniProt Gene Name:TGFBRAP1  
UniProt Entry Name:TGFA1_HUMAN
Anti-TGFBRAP1 Antibody (CAB14386)Western blot analysis of extracts of various cell lines, using TGFBRAP1 antibody (CAB14386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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