Cell Biology Antibodies 17

Anti-TGFBI Antibody (CAB2407)

(No reviews yet) Write a Review
SKU:
CAB2407
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TGFBI Antibody
Antibody SKU:CAB2407
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TGFBI
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Mouse heart, Rat testis, Rat kidney
Immunogen:A synthesized peptide derived from human TGFBI
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7045
Uniprot:Q15582
Cellular Location:
Calculated MW:68kDa
Observed MW:66KDa
Synonyms:BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Background:This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Protein Function:betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cell adhesion; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region; plasma membrane; basement membrane; trans-Golgi network

Molecular Function:collagen binding; integrin binding; protein binding; extracellular matrix binding

Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion

Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy, Avellino Type; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I

NCBI Summary:This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Code:Q15582
NCBI GenInfo Identifier:2498193
NCBI Gene ID:7045
NCBI Accession:Q15582.1
UniProt Secondary Accession:Q15582,O14471, O14472, O14476, O43216, O43217, O43218 O43219, Q53XM1, D3DQB1,
UniProt Related Accession:Q15582
Molecular Weight:74,681 Da
NCBI Full Name:Transforming growth factor-beta-induced protein ig-h3
NCBI Synonym Full Names:transforming growth factor, beta-induced, 68kDa
NCBI Official Symbol:TGFBI  
NCBI Official Synonym Symbols:CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1  
NCBI Protein Information:transforming growth factor-beta-induced protein ig-h3; RGD-CAP; beta ig-h3; kerato-epithelin; RGD-containing collagen-associated protein; transforming growth factor, beta-induced, 68kD
UniProt Protein Name:Transforming growth factor-beta-induced protein ig-h3
UniProt Synonym Protein Names:Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
Protein Family:Transforming growth factor-beta-induced protein
UniProt Gene Name:TGFBI  
UniProt Entry Name:BGH3_HUMAN
Anti-TGFBI Antibody (CAB2407)Western blot - TGFBI Rabbit mAb (CAB2407)
View AllClose

0 Reviews

View AllClose

Related Products