Cell Biology Antibodies 12

Anti-TGFB3 Antibody (CAB8460)

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SKU:
CAB8460
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TGFB3 Antibody
Antibody SKU:CAB8460
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_003230.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, K-937, Mouse lung, Mouse skeletal muscle, Mouse heart, Rat lung, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_003230.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:STCT TLDF GHIK KKRV EAIR GQIL SKLR LTSP PEPT VMTH VPYQ VLAL YNST RELL EEMH GERE EGCT QENT ESEY YAKE IHKF DMIQ GLAE HNEL AVCP KGIT SKVF RFNV SSVE KNRT NLFR AEFR VLRV PNPS SKRN EQRI ELFQ ILRP DEHI AKQR YIGG KNLP TRGT AEWL SFDV TDTV REWL LRRE SNLG LEIS IHCP CHTF QPNG DILE NIHE VMEI KFKG VDNE DDHG RGDL GRLK KQKD HHNP HLIL MMIP PHRL DNPG QGGQ RKKR
Gene ID:7043
Uniprot:P10600
Cellular Location:Secreted
Calculated MW:35kDa/47kDa
Observed MW:60kDa
Synonyms:TGFB3, ARVD, ARVD1, LDS5, RNHF, TGF-beta3
Background:This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1.
UniProt Protein Function:TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding

Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

NCBI Summary:This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
UniProt Code:P10600
NCBI GenInfo Identifier:135684
NCBI Gene ID:7043
NCBI Accession:P10600.1
UniProt Secondary Accession:P10600,Q8WV88,
UniProt Related Accession:P10600
Molecular Weight:35,708 Da
NCBI Full Name:Transforming growth factor beta-3
NCBI Synonym Full Names:transforming growth factor beta 3
NCBI Official Symbol:TGFB3  
NCBI Official Synonym Symbols:ARVD; LDS5; RNHF; ARVD1; TGF-beta3  
NCBI Protein Information:transforming growth factor beta-3
UniProt Protein Name:Transforming growth factor beta-3
Protein Family:Transforming growth factor
UniProt Gene Name:TGFB3  
UniProt Entry Name:TGFB3_HUMAN
Anti-TGFB3 Polyclonal Antibody (CAB8460)Western blot analysis of extracts of various cell lines, using TGFB3 antibody (CAB8460) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TGFB3 Polyclonal Antibody (CAB8460)Immunohistochemistry of paraffin-embedded mouse lung using TGFB3 antibody (CAB8460) at dilution of 1:100 (40x lens).
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