Metabolism Antibodies 1

Anti-TG Antibody (CAB11708)

(No reviews yet) Write a Review
SKU:
CAB11708
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TG Antibody
Antibody SKU:CAB11708
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2469-2768 of human TG (NP_003226.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2469-2768 of human TG (NP_003226.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLAV SGPF HYWG PVID GHFL REPP ARAL KRSL WVEV DLLI GSSQ DDGL INRA KAVK QFEE SRGR TSSK TAFY QALQ NSLG GEDS DARV EAAA TWYY SLEH STDD YASF SRAL ENAT RDYF IICP IIDM ASAW AKRA RGNV FMYH APEN YGHG SLEL LADV QFAL GLPF YPAY EGQF SLEE KSLS LKIM QYFS HFIR SGNP NYPY EFSR KVPT FATP WPDF VPRA GGEN YKEF SELL PNRQ GLKK ADCS FWSK YISS LKTS ADGA KGGQ SAES EEEE LTAG SGLR EDLL SLQE PGSK TYSK
Gene ID:7038
Uniprot:P01266
Cellular Location:Secreted
Calculated MW:298kDa/304kDa
Observed MW:290kDa
Synonyms:TG, AITD3, TGN
Background:Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
UniProt Protein Function:Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
NCBI Summary:Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
UniProt Code:P01266
NCBI GenInfo Identifier:126302607
NCBI Gene ID:7038
NCBI Accession:P01266.5
UniProt Secondary Accession:P01266,O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2 Q9UMZ0, Q9UNY3,
UniProt Related Accession:P01266
Molecular Weight:298,383 Da
NCBI Full Name:Thyroglobulin
NCBI Synonym Full Names:thyroglobulin
NCBI Official Symbol:TG  
NCBI Official Synonym Symbols:TGN; AITD3  
NCBI Protein Information:thyroglobulin
UniProt Protein Name:Thyroglobulin
Protein Family:Thyroglobulin
UniProt Gene Name:TG  
Anti-TG Antibody (CAB11708)Western blot analysis of extracts of HeLa cells, using TG antibody (CAB11708) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products