Cell Biology Antibodies 12
Anti-TFR2 Antibody (CAB9845)
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- SKU:
- CAB9845
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TFR2 Antibody |
| Antibody SKU: | CAB9845 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 582-801 of human TFR2 (NP_003218.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 582-801 of human TFR2 (NP_003218.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVEF SFME DDQA YPFL HTKE DTYE NLHK VLQG RLPA VAQA VAQL AGQL LIRL SHDR LLPL DFGR YGDV VLRH IGNL NEFS GDLK ARGL TLQW VYSA RGDY IRAA EKLR QEIY SSEE RDER LTRM YNVR IMRV EFYF LSQY VSPA DSPF RHIF MGRG DHTL GALL DHLR LLRS NSSG TPGA TSST GFQE SRFR RQLA LLTW TLQG AANA LSGD VWNI DNNF |
| Gene ID: | 7036 |
| Uniprot: | Q9UP52 |
| Cellular Location: | Cell membrane, Cytoplasm, Single-pass type II membrane protein |
| Calculated MW: | 69kDa/86kDa/88kDa |
| Observed MW: | 89kDa |
| Synonyms: | TFR2, HFE3, TFRC2 |
| Background: | This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22 Cellular Component: cytoplasmic vesicle; external side of plasma membrane; integral to plasma membrane Molecular Function:glycoprotein binding; protein binding; transferrin receptor activity Biological Process: cellular iron ion homeostasis; iron ion homeostasis; positive regulation of endocytosis; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to iron ion; transferrin transport Disease: Hemochromatosis, Type 3 |
| NCBI Summary: | This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | Q9UP52 |
| NCBI GenInfo Identifier: | 20140912 |
| NCBI Gene ID: | 7036 |
| NCBI Accession: | Q9UP52.1 |
| UniProt Secondary Accession: | Q9UP52,O75422, Q1HE13, Q9HA99, Q9NX67, A6NGM7, |
| UniProt Related Accession: | Q9UP52 |
| Molecular Weight: | |
| NCBI Full Name: | Transferrin receptor protein 2 |
| NCBI Synonym Full Names: | transferrin receptor 2 |
| NCBI Official Symbol: | TFR2 |
| NCBI Official Synonym Symbols: | HFE3; TFRC2 |
| NCBI Protein Information: | transferrin receptor protein 2 |
| UniProt Protein Name: | Transferrin receptor protein 2 |
| Protein Family: | Transferrin receptor protein |
| UniProt Gene Name: | TFR2 |
| UniProt Entry Name: | TFR2_HUMAN |
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