Cardiovascular Antibodies
Anti-TFPI2 Antibody (CAB6214)
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- SKU:
- CAB6214
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-TFPI2 Antibody |
| Antibody SKU: | CAB6214 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-235 of human TFPI2 (NP_006519.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-235 of human TFPI2 (NP_006519.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DAAQ EPTG NNAE ICLL PLDY GPCR ALLL RYYY DRYT QSCR QFLY GGCE GNAN NFYT WEAC DDAC WRIE KVPK VCRL QVSV DDQC EGST EKYF FNLS SMTC EKFF SGGC HRNR IENR FPDE ATCM GFCA PKKI PSFC YSPK DEGL CSAN VTRY YFNP RYRT CDAF TYTG CGGN DNNF VSRE DCKR ACAK ALKK KKKM PKLR FASR IRKI RKKQ F |
| Gene ID: | 7980 |
| Uniprot: | P48307 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa/26kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TFPI2, PP5, REF1, TFPI-2 |
| Background: | This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q22 Cellular Component: proteinaceous extracellular matrix; nucleus Molecular Function:serine-type endopeptidase inhibitor activity; extracellular matrix structural constituent Biological Process: blood coagulation |
| NCBI Summary: | This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P48307 |
| NCBI GenInfo Identifier: | 1351226 |
| NCBI Gene ID: | 7980 |
| NCBI Accession: | P48307.1 |
| UniProt Secondary Accession: | P48307,Q66ME8, Q8NAK6, Q9UC86, |
| UniProt Related Accession: | P48307 |
| Molecular Weight: | 25,796 Da |
| NCBI Full Name: | Tissue factor pathway inhibitor 2 |
| NCBI Synonym Full Names: | tissue factor pathway inhibitor 2 |
| NCBI Official Symbol: | TFPI2 |
| NCBI Official Synonym Symbols: | PP5; REF1; TFPI-2 |
| NCBI Protein Information: | tissue factor pathway inhibitor 2; placental protein 5; retinal pigment epithelium cell factor 1 |
| UniProt Protein Name: | Tissue factor pathway inhibitor 2 |
| UniProt Synonym Protein Names: | Placental protein 5; PP5 |
| Protein Family: | Tissue factor pathway inhibitor |
| UniProt Gene Name: | TFPI2 |
| UniProt Entry Name: | TFPI2_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TFPI2 antibody (CAB6214) at dilution of 1:200 (40x lens). |
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